UniProt Accession

 CD83_HUMAN; Q01151; Q5THX9 

Genbank Protein ID

 Z11697; S53354; CR457019; AL133259; AL022396; AL022396; AL133259; BC030830 

Genbank Nucleotide ID

 CAA77755.1; AAB25085.1; CAG33300.1; CAB96723.2; CAB96723.2; CAI20374.1; CAI20374.1; AAH30830.1 

Protein Name

 CD83 antigen 

Protein Synonyms/Alias

 hCD83; B-cell activation protein; Cell surface protein HB15; CD83 

Gene Name

 CD83 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
177	SIFPDFSKAGMERAF	ubiquitination	[1]
192	LPVTSPNKHLGLVTP	ubiquitination	[2, 3]
201	LGLVTPHKTELV***	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. 

Sequence Annotation

 DOMAIN 20 114 Ig-like V-type.
 CARBOHYD 79 79 N-linked (GlcNAc...).
 CARBOHYD 86 86 N-linked (GlcNAc...); atypical.
 CARBOHYD 96 96 N-linked (GlcNAc...) (Potential).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 DISULFID 35 107 Potential.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0032713; P:negative regulation of interleukin-4 production; IEA:Compara.
 GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Compara.
 GO:0032733; P:positive regulation of interleukin-10 production; IEA:Compara.
 GO:0032743; P:positive regulation of interleukin-2 production; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS