CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription initiation factor IIA subunit 1 
Protein Synonyms/Alias
 General transcription factor IIA subunit 1; dTFIIA-L; Transcription initiation factor IIA alpha chain; TFIIA p30 subunit; Transcription initiation factor IIA beta chain; TFIIA p20 subunit 
Gene Name
 TfIIA-L 
Gene Synonyms/Alias
 CG5930 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
353GIMNMRGKDYVFQKSacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. 
Sequence Annotation
 MOD_RES 265 265 Phosphoserine; by TAF1 (By similarity).
 MOD_RES 306 306 Phosphoserine; by TAF1 (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MALCQTSVLK VYHAVIEDVI TNVRDAFLDE GVDEQVLQEM KQVWRNKLLA SKAVELSPDS 60
GDGSHPPPIV ANNPKSHKAA NAKAKKAAAA TAVTSHQHIG GNSSMSSLVG LKSSAGMAAG 120
SGIRNGLVPI KQEVNSQNPP PLHPTSAASM MQKQQQAASS GQGSIPIVAT LDPNRIMPVN 180
ITLPSPAGSA SSESRVLTIQ VPASALQENQ LTQILTAHLI SSIMSLPTTL ASSVLQQHVN 240
AALSSANHQK TLAAAKQLDG ALDSSDEDES EESDDNIDND DDDDLDKDDD EDAEHEDAAE 300
EEPLNSEDDV TDEDSAEMFD TDNVIVCQYD KITRSRNKWK FYLKDGIMNM RGKDYVFQKS 360
NGDAEW 366 
Gene Ontology
 GO:0005672; C:transcription factor TFIIA complex; IDA:FlyBase.
 GO:0001129; F:TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly; IPI:FlyBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase. 
Interpro
 IPR009083; TFIIA_a-hlx.
 IPR004855; TFIIA_asu/bsu.
 IPR013028; TFIIA_asu_N.
 IPR009088; TFIIA_b-brl. 
Pfam
 PF03153; TFIIA 
SMART
  
PROSITE
  
PRINTS