UniProt Accession

 APOC3_RAT; P06759 

Genbank Protein ID

 J02596 

Genbank Nucleotide ID

 AAA40746.1 

Protein Name

 Apolipoprotein C-III 

Protein Synonyms/Alias

 Apo-CIII; ApoC-III; Apolipoprotein C3 

Gene Name

 Apoc3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
72	DNRFKSLKGYWSKFT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. 

Sequence Annotation

 REGION 69 101 Lipid-binding (By similarity).
 CARBOHYD 96 96 O-linked (GalNAc...) (By similarity).  

Keyword

 Chylomicron; Complete proteome; Glycoprotein; Lipid degradation; Lipid metabolism; Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 101 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0034363; C:intermediate-density lipoprotein particle; IEA:Compara.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0005319; F:lipid transporter activity; TAS:RGD.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IDA:RGD.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0034382; P:chylomicron remnant clearance; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Compara.
 GO:0006954; P:inflammatory response; IEP:RGD.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0042953; P:lipoprotein transport; IDA:RGD.
 GO:0060621; P:negative regulation of cholesterol import; IEA:Compara.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0010987; P:negative regulation of high-density lipoprotein particle clearance; IEA:Compara.
 GO:0051005; P:negative regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IEA:Compara.
 GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Compara.
 GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:Compara.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IDA:RGD.
 GO:0019433; P:triglyceride catabolic process; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara.
 GO:0006642; P:triglyceride mobilization; IEA:Compara. 

Interpro

 IPR008403; Apo-CIII. 

Pfam

 PF05778; Apo-CIII 

SMART

  

PROSITE

  

PRINTS