CPLM-018081

Genbank Nucleotide ID

Partitioning defective 3 homolog

Protein Synonyms/Alias

PAR-3; PARD-3; Atypical PKC isotype-specific-interacting protein; ASIP; CTCL tumor antigen se2-5; PAR3-alpha

Homo sapiens (Human)

Position	Peptide	Type	References
374	EQLSQSEKNNYYSSR	ubiquitination	[1]
1005	EKKKDRDKEKDKMKA	acetylation	[2]
1007	KKDRDKEKDKMKAKK	acetylation	[2]

[1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]

Functional Description

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

DOMAIN 271 359 PDZ 1.
DOMAIN 461 546 PDZ 2.
DOMAIN 590 677 PDZ 3.
REGION 712 936 Interacts with PRKCI and PRKCZ (By
MOD_RES 144 144 Phosphoserine (By similarity).
MOD_RES 383 383 Phosphoserine.
MOD_RES 692 692 Phosphoserine.
MOD_RES 695 695 Phosphoserine.
MOD_RES 717 717 Phosphoserine (By similarity).
MOD_RES 728 728 Phosphoserine.
MOD_RES 809 809 Phosphoserine.
MOD_RES 827 827 Phosphoserine (By similarity).
MOD_RES 852 852 Phosphoserine.
MOD_RES 873 873 Phosphoserine.
MOD_RES 962 962 Phosphoserine; by AURKA.

3D-structure; Alternative splicing; Cell cycle; Cell division; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Tight junction.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0045177; C:apical part of cell; IEA:Compara.
GO:0044295; C:axonal growth cone; IEA:Compara.
GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0005913; C:cell-cell adherens junction; IEA:Compara.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
GO:0043025; C:neuronal cell body; IEA:Compara.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005819; C:spindle; IEA:Compara.
GO:0005923; C:tight junction; IDA:UniProtKB.
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.
GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.
GO:0003383; P:apical constriction; IEA:Compara.
GO:0008356; P:asymmetric cell division; TAS:ProtInc.
GO:0007409; P:axonogenesis; TAS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051642; P:centrosome localization; IEA:Compara.
GO:0090162; P:establishment of epithelial cell polarity; ISS:UniProtKB.
GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
GO:0006461; P:protein complex assembly; TAS:ProtInc.
GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; TAS:UniProtKB.
GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.
GO:0032970; P:regulation of actin filament-based process; IEA:Compara.
GO:0060341; P:regulation of cellular localization; IEA:Compara.
GO:0070830; P:tight junction assembly; ISS:UniProtKB.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.
GO:0044319; P:wound healing, spreading of cells; IEA:Compara.

IPR021922; DUF3534.
IPR001478; PDZ.

PF12053; DUF3534
PF00595; PDZ