CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023025
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Hook homolog 1 
Protein Synonyms/Alias
 h-hook1; hHK1 
Gene Name
 HOOK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
245DPNTVVAKKYFHAQLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). 
Sequence Annotation
 REGION 1 555 Sufficient for interaction with
 REGION 657 728 Sufficient for interaction with AKTIP and
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 699 699 Phosphothreonine.
 MOD_RES 719 719 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Microtubule; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Spermatogenesis; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 728 AA 
Protein Sequence
MEETQPPPQP KLPLCDSLMI WLQTFNTASP CQDVKQLTSG VAMAQVLHQI DAAWFNESWL 60
SRIKEDVGDN WRIKASNVKK VLQGIMSYYH EFLGQQISEA LIPDLNQITE CSDPVELGRL 120
LQLILGCAIN CEKKQEHIQN IMTLEESVQH VVMTAIQELM SKEILSSPPN DAVGELEQQL 180
KRALEELQEA LAEKEELRQR CEELDMQVTT LQDEKNSLVS ENEMMNEKLD QLDGSFDDPN 240
TVVAKKYFHA QLQLEQLQEE NFRLEAAKDD YRVHCEELEK QLIEFQHRND ELTSLAEETR 300
ALKDEIDVLR ATSDKANKLE STVEIYRQKL QDLNDLRKQV KTLQETNMMY MHNTVSLEEE 360
LKKANAARTQ LETYKRQVQD LHVKLSSESK RADTLAFEMK RLEEKHEALL KEKERLIEQR 420
DTLKETNEEL RCSQVQQDHL NQTDASATKS YENLAAEIMP VEYREVFIRL QHENKMLRLQ 480
QEGSENERIE ELQEQLEQKH RKMNELETEQ RLSKERIREL QQQIEDLQKS LQEQGSKSEG 540
ESSSKLKQKL EAHMEKLTEV HEELQKKQEL IEDLQPDINQ NVQKINELEA ALQKKDEDMK 600
AMEERYKMYL EKARNVIKTL DPKLNPASAE IMLLRKQLAE KERRIEILES ECKVAKFRDY 660
EEKLIVSAWY NKSLAFQKLG MESRLVSGGG ACSDTGACTP ARSFLAQQRH ITNTRRNLSV 720
KVPATTSD 728 
Gene Ontology
 GO:0070695; C:FHF complex; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0045022; P:early endosome to late endosome transport; IMP:UniProtKB.
 GO:0007032; P:endosome organization; IMP:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; IMP:UniProtKB.
 GO:0007040; P:lysosome organization; IMP:UniProtKB.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007286; P:spermatid development; IEA:Compara. 
Interpro
 IPR008636; HOOK/CCDC88. 
Pfam
 PF05622; HOOK 
SMART
  
PROSITE
  
PRINTS