CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010391
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
 GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI 
Gene Name
 pgi 
Gene Synonyms/Alias
 MPN_250; MP582 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
4****MESKWLTVDTKacetylation[1]
24DEAIFIQKYQKKVNQacetylation[1]
107PEQKANIKVHFVPDIacetylation[1]
426YKQLMFAKLGRE***acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
  
Sequence Annotation
 ACT_SITE 284 284 Proton donor (By similarity).
 ACT_SITE 305 305 By similarity.
 ACT_SITE 420 420 By similarity.  
Keyword
 Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 430 AA 
Protein Sequence
MESKWLTVDT KHLYGFDEAI FIQKYQKKVN QIHQQFLNQQ LPDGHMNGWY SQPDQDHKGL 60
LKQINTIAKQ FNALKVTDIV YLGIGGSYTG IRAILDFLKP EQKANIKVHF VPDISAFNIA 120
AVARAIKGKS WALVVTSKSG RTLEPAVTFR YFRNLLHKQY KQKHALRTVV ITDAVKGLLV 180
GMSNQYGYAH LTIPSNIGGR FSTLSPAGLL LAKLCGHDPK QLLLGTLTAK QELANSDLNT 240
NSAYYYAALR HWLYTTKKLK IEVTVAYHSA YEYLLLQHRQ LFGESEGKGG KSLFPTFSLF 300
TTDLHSMGQL YQEGEKNFFE TVIQVQTQFH DLELPPSDFN NDDQLDYLLA KSMNEISNTA 360
LEAVVEAHFQ SNVNIIKLTL KERTTFMFGY FYFWLSMATM MSGSLLGHNV FDQPGVEVYK 420
QLMFAKLGRE 430 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:HAMAP.
 GO:0006094; P:gluconeogenesis; IEA:HAMAP.
 GO:0006096; P:glycolysis; IEA:HAMAP. 
Interpro
 IPR001672; G6P_Isomerase.
 IPR018189; Phosphoglucose_isomerase_CS. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS
 PR00662; G6PISOMERASE.