UniProt Accession

 FKB1B_RAT; P97534 

Genbank Protein ID

 D86642 

Genbank Nucleotide ID

 BAA13154.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP1B 

Protein Synonyms/Alias

 PPIase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; Calstabin-2; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase 

Gene Name

 Fkbp1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
45	DSSRDRNKPFKFRIG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 20 108 PPIase FKBP-type.  

Keyword

 Complete proteome; Cytoplasm; Isomerase; Reference proteome; Rotamase; Sarcoplasmic reticulum. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0034704; C:calcium channel complex; IBA:RefGenome.
 GO:0033017; C:sarcoplasmic reticulum membrane; IBA:RefGenome.
 GO:0030551; F:cyclic nucleotide binding; IDA:RGD.
 GO:0005528; F:FK506 binding; IDA:RGD.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:RGD.
 GO:0030073; P:insulin secretion; IEA:Compara.
 GO:0010459; P:negative regulation of heart rate; IEA:Compara.
 GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Compara.
 GO:0032513; P:negative regulation of protein phosphatase type 2B activity; IBA:RefGenome.
 GO:0019227; P:neuronal action potential propagation; IEA:Compara.
 GO:0048680; P:positive regulation of axon regeneration; IDA:RGD.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IBA:RefGenome.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0051775; P:response to redox state; IEA:Compara.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0006939; P:smooth muscle contraction; IEA:Compara.
 GO:0042098; P:T cell proliferation; IEA:Compara. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS