CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030520
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ34145 fis, clone FCBBF3011867, highly similar to ADAM 19 (EC 3.4.24.-) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
474KPSALPSKLRQQFSCubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Disulfide bond. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 638 AA 
Protein Sequence
MCEVSENPYS TLWSFLGWRR KLLAQKYHDN AQLITGMSFH GTTIGLAPLM AMCSVYQSGG 60
VNMDHSENAI GVAATMAHEM GHNFGMTHDS ADCCSASAAD GGCIMAAATG HPFPKVFNGC 120
NRRELDRYLQ SGGGMCLSNM PDTRMLYGGR RCGNGYLEDG EECDCGEEEE CNNPCCNASN 180
CTLRPGAECA HGSCCHQCKL LAPGTLCREQ ARQCDLPEFC TGKSPHCPTN FYQMDGTPCE 240
GGQAYCYNGM CLTYQEQCQQ LWGPGARPAP DLCFEKVNVA GDTFGNCGKD MNGEHRKCNM 300
RDAKCGKIQC QSSEARPLES NAVPIDTTII MNGRQIQCRG THVYRGPEEE GDMLDPGLVM 360
TGTKCGYNHI CFEGQCRNTS FFETEGCGKK CNGHGVCNNN QNCHCLPGWA PPFCNTPGHG 420
GSIDSGPMPP ESVGPVVAGV LVAILVLAVL MLMYYCCRQN NKLGQLKPSA LPSKLRQQFS 480
CPFRVSQNSG TGHANPTFKL QTPQGKRKVI NTPEILRKPS QPPPRPPPDY LRGGSPPAPL 540
PAHLSRAARN SPGPGSQIER TESSRRPPPS RPIPPAPNCI VSQKCLLPPA MILRAPQPSG 600
TVVCLVISFN MAFYRSMRIR IEPGIKTKLL VLLVWKQF 638 
Gene Ontology
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR006586; ADAM_Cys-rich.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR018358; Disintegrin_CS.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B. 
Pfam
 PF08516; ADAM_CR
 PF00200; Disintegrin
 PF01421; Reprolysin 
SMART
 SM00608; ACR
 SM00050; DISIN 
PROSITE
 PS50215; ADAM_MEPRO
 PS00427; DISINTEGRIN_1
 PS50214; DISINTEGRIN_2
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS
 PR00289; DISINTEGRIN.