UniProt Accession

 TUSC2_HUMAN; O75896; B2R4Y9 

Genbank Protein ID

 AF055479; AK311998; CH471055; BC023976 

Genbank Nucleotide ID

 AAC35497.1; BAG34936.1; EAW65097.1; AAH23976.1 

Protein Name

 Tumor suppressor candidate 2 

Protein Synonyms/Alias

 Fusion 1 protein; Fus-1 protein; PDGFA-associated protein 2 

Gene Name

 TUSC2 

Gene Synonyms/Alias

 C3orf11; FUS1; LGCC; PDAP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	LIPQGIVKLDHPRIH	acetylation	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. 

Sequence Annotation

 MOD_RES 50 50 Phosphoserine.
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 Cell cycle; Complete proteome; Lipoprotein; Myristate; Phosphoprotein; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0032618; P:interleukin-15 production; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS