UniProt Accession

 TFR1_MOUSE; Q62351; Q61560 

Genbank Protein ID

 X57349; BC054522; M29618 

Genbank Nucleotide ID

 CAA40624.1; AAH54522.1; AAA37616.1 

Protein Name

 Transferrin receptor protein 1 

Protein Synonyms/Alias

 TR; TfR; TfR1; Trfr; CD71 

Gene Name

 Tfrc 

Gene Synonyms/Alias

 Trfr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	DNSHVEMKLAADEEE	ubiquitination	[1]
53	ENADNNMKASVRKPK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). 

Sequence Annotation

 DOMAIN 225 315 PA.
 REGION 1 67 Mediates interaction with SH3BP4 (By
 REGION 572 763 Ligand-binding (By similarity).
 MOTIF 20 23 Endocytosis signal.
 MOTIF 58 61 Stop-transfer sequence.
 MOTIF 649 651 Cell attachment site (Potential).
 MOD_RES 20 20 Phosphotyrosine.
 MOD_RES 21 21 Phosphothreonine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 LIPID 67 67 S-palmitoyl cysteine (By similarity).
 CARBOHYD 104 104 O-linked (GalNAc...) (By similarity).
 CARBOHYD 253 253 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 319 319 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 725 725 N-linked (GlcNAc...).
 CARBOHYD 730 730 N-linked (GlcNAc...).
 DISULFID 89 89 Interchain (By similarity).
 DISULFID 98 98 Interchain (By similarity).  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 763 AA 

Protein Sequence

Gene Ontology

 GO:0005905; C:coated pit; IEA:Compara.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISO:MGI.
 GO:0005768; C:endosome; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0070062; C:extracellular vesicular exosome; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0005381; F:iron ion transmembrane transporter activity; TAS:MGI.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0004998; F:transferrin receptor activity; TAS:MGI.
 GO:0006879; P:cellular iron ion homeostasis; IMP:MGI.
 GO:0030316; P:osteoclast differentiation; IMP:DFLAT.
 GO:0045780; P:positive regulation of bone resorption; IDA:DFLAT.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR007484; Peptidase_M28.
 IPR003137; Protease-assoc_domain.
 IPR007365; TFR-like_dimer_dom. 

Pfam

 PF02225; PA
 PF04389; Peptidase_M28
 PF04253; TFR_dimer 

SMART

  

PROSITE

  

PRINTS