UniProt Accession

 D3YVR0_MOUSE; D3YVR0 

Genbank Protein ID

 AC163616 

Genbank Nucleotide ID

  

Protein Name

 Tropomyosin alpha-3 chain 

Protein Synonyms/Alias

  

Gene Name

 Tpm3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	VIENRALKDEEKMEL	acetylation	[1]
10	VIENRALKDEEKMEL	ubiquitination	[2]
14	RALKDEEKMELQEIQ	acetylation	[1]
14	RALKDEEKMELQEIQ	ubiquitination	[2]
23	ELQEIQLKEAKHIAE	acetylation	[1, 3]
23	ELQEIQLKEAKHIAE	ubiquitination	[2]
26	EIQLKEAKHIAEEAD	acetylation	[4]
35	IAEEADRKYEEVARK	acetylation	[1]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 71 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0002102; C:podosome; IDA:MGI.
 GO:0001725; C:stress fiber; ISO:MGI. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

  

PRINTS

 PR00194; TROPOMYOSIN.