UniProt Accession

 DPM1_YEAST; P14020; D6W4I3 

Genbank Protein ID

 J04184; U25842; BK006949 

Genbank Nucleotide ID

 AAA34578.1; AAB68116.1; DAA11599.1 

Protein Name

 Dolichol-phosphate mannosyltransferase 

Protein Synonyms/Alias

 Dolichol-phosphate mannose synthase; DPM synthase; Dolichyl-phosphate beta-D-mannosyltransferase; Mannose-P-dolichol synthase; MPD synthase 

Gene Name

 DPM1 

Gene Synonyms/Alias

 SED3; YPR183W; P9705.3 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
81	GLSSAVLKGFYEAKG	acetylation	[1]
167	GFFGLQKKYLENCNP	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 141 141 Phosphoserine; by PKA.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycosyltransferase; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IDA:SGD.
 GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IDA:SGD.
 GO:0006506; P:GPI anchor biosynthetic process; IMP:SGD.
 GO:0006487; P:protein N-linked glycosylation; IMP:SGD.
 GO:0006493; P:protein O-linked glycosylation; IMP:SGD. 

Interpro

 IPR001173; Glyco_trans_2. 

Pfam

 PF00535; Glycos_transf_2 

SMART

  

PROSITE

  

PRINTS