| Tag | Content |
|---|
| CPLM ID | CPLM-022589 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras/Rap GTPase-activating protein SynGAP |
Protein Synonyms/Alias | Neuronal RasGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; p135 SynGAP |
Gene Name | Syngap1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 791 | ARLPSPTKEKPPPPP | ubiquitination | [1] | | 793 | LPSPTKEKPPPPPPG | ubiquitination | [1] | | 839 | QKMLSVNKSVSMLDL | ubiquitination | [1] | | 1130 | GGGGGGLKPSITKQH | ubiquitination | [1] | | 1196 | ESRLDRVKEYEEEIH | ubiquitination | [1] | | 1232 | SQEEQTSKILMQYQA | ubiquitination | [1] | | 1260 | VEKDSQIKSIIGRLM | ubiquitination | [1] | | 1288 | AEPLPEPKKRLLDAQ | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating speciticity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
Sequence Annotation | DOMAIN 150 251 PH.
DOMAIN 249 347 C2.
DOMAIN 443 635 Ras-GAP.
REGION 1197 1308 Interaction with MPDZ.
MOTIF 785 815 SH3-binding (Potential).
MOTIF 1305 1308 PDZ-binding (Potential).
MOD_RES 379 379 Phosphoserine; by PLK2.
MOD_RES 385 385 Phosphoserine; by PLK2.
MOD_RES 449 449 Phosphoserine; by PLK2.
MOD_RES 466 466 Phosphoserine; by PLK2.
MOD_RES 836 836 Phosphoserine; by PLK2.
MOD_RES 840 840 Phosphoserine; by PLK2.
MOD_RES 842 842 Phosphoserine; by PLK2.
MOD_RES 895 895 Phosphoserine; by PLK2. |
Keyword | 3D-structure; Alternative splicing; Cell junction; Complete proteome; Direct protein sequencing; GTPase activation; Membrane; Phosphoprotein; Reference proteome; SH3-binding; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1308 AA |
Protein Sequence | MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI ISGNQLLMLD 60
EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY HLGRSRRKSV PGGKQYSMEA 120
APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL DRTSSFRQIL PRFRSADHDR ARLMQSFKES 180
HSHESLLSPS SAAEALELNL DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD 240
KWIENLQRAV KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 300
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV ATLAGRHFTE 360
QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV RLKARYQTMS ILPMELYKEF 420
AEYVTNHYRM LCAVLEPALN VKGKEEVASA LVHILQSTGK AKDFLSDMAM SEVDRFMERE 480
HLIFRENTLA TKAIEEYMRL IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ 540
ANLRMCCELA LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 600
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN EFLELEWGSM 660
QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL PQLSKEALLK LGPLPRLLSD 720
ISTALRNPNI QRQPSRQSER ARSQPMVLRG PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS 780
MDMARLPSPT KEKPPPPPPG GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS 840
VSMLDLQGDG PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT 900
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG HGPPSSHHHH 960
HHHHHHRGGE PPGDTFAPFH GYSKSEDLST GVPKPPAASI LHSHSYSDEF GPSGTDFTRR 1020
QLSLQDNLQH MLSPPQITIG PQRPAPSGPG GGSGGGSGGG GGGQPPPLQR GKSQQLTVSA 1080
AQKPRPSSGN LLQSPEPSYG PARPRQQSLS KEGSIGGSGG SGGGGGGGLK PSITKQHSQT 1140
PSTLNPTMPA SERTVAWVSN MPHLSADIES AHIEREEYKL KEYSKSMDES RLDRVKEYEE 1200
EIHSLKERLH MSNRKLEEYE RRLLSQEEQT SKILMQYQAR LEQSEKRLRQ QQVEKDSQIK 1260
SIIGRLMLVE EELRRDHPAM AEPLPEPKKR LLDAQRGSFP PWVQQTRV 1308 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. GO:0014069; C:postsynaptic density; IDA:RGD. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005099; F:Ras GTPase activator activity; IDA:RGD. GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB. GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |