CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012909
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-fructose oxidoreductase domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 GFOD2 
Gene Synonyms/Alias
 UNQ9430/PRO34691 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84LTRQISVKALGIGKNubiquitination[1]
90VKALGIGKNVVCEKAubiquitination[1, 2]
96GKNVVCEKAATSVDAubiquitination[1, 3]
271GADLYGQKNSATQEEubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Promotes matrix assembly (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Extracellular matrix; Oxidoreductase; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MKMLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI AFYTSRTDDI 60
LLHQDVDLVC ISIPPPLTRQ ISVKALGIGK NVVCEKAATS VDAFRMVTAS RYYPQLMSLV 120
GNVLRFLPAF VRMKQLISEH YVGAVMICDA RIYSGSLLSP SYGWICDELM GGGGLHTMGT 180
YIVDLLTHLT GRRAEKVHGL LKTFVRQNAA IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN 240
FNMPGAFVHE VMVVGSAGRL VARGADLYGQ KNSATQEELL LRDSLAVGAG LPEQGPQDVP 300
LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA IKRSSRSGEW 360
EAVEVLTEEP DTNQNLCEAL QRNNL 385 
Gene Ontology
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0030198; P:extracellular matrix organization; IEA:Compara. 
Interpro
 IPR016040; NAD(P)-bd_dom.
 IPR000683; Oxidoreductase_N. 
Pfam
 PF01408; GFO_IDH_MocA 
SMART
  
PROSITE
  
PRINTS