| Tag | Content |
|---|
| CPLM ID | CPLM-020901 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Corepressor interacting with RBPJ 1 |
Protein Synonyms/Alias | CBF1-interacting corepressor |
Gene Name | Cir1 |
Gene Synonyms/Alias | Cir |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 3 | *****MGKSFANFMC | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre-mRNAs. |
Sequence Annotation | REGION 1 121 Interaction with RBPJ (By similarity).
REGION 204 232 Interaction with RP9.
MOTIF 235 247 Nuclear localization signal (Potential).
MOTIF 307 314 Nuclear localization signal (Potential).
MOD_RES 202 202 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 450 AA |
Protein Sequence | MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ ESYDNRLLMG 60
DERVKNGLNF MYEAPPGVKK ENKEKEETEG ETEYKFEWQK GAPREKYAKD DMNIRDQPFG 120
IQVRNVRCIK CHKWGHVNTD RECPLFGLSG INASSVPTDG SGPSMHPSEL IAEMRNSGFA 180
LKRNVLGRNL TANDPSQDYV ASDCEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKKS 240
DKKKKKLQKS KNKHKKRKNK SPSSSSSSSS SSSSSSSSSS SSSSSSETSD SSSESDNKEK 300
KREKEKRKKK KKTKCSESKS SDCKEDKPKN MLYEELSSSH SDRGKAQEKL RFPKQESSGE 360
NSMWVHSASD RTSRSHRHSP EKKGSDRNRG IRSRSRSRAE SSRRSRSRSP YRQKHREVRS 420
RPHRSPSEEQ KGRKGTRSHG EGDHRREHVR 450 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0000118; C:histone deacetylase complex; IEA:Compara. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0016607; C:nuclear speck; ISA:MGI. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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