| Tag | Content |
|---|
| CPLM ID | CPLM-016093 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 4 gamma 3 |
Protein Synonyms/Alias | eIF-4-gamma 3; eIF-4G 3; eIF4G 3; eIF-4-gamma II; eIF4GII |
Gene Name | Eif4g3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1286 | VQSEKLSKQDFFKGF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (By similarity). |
Sequence Annotation | REPEAT 740 778 HEAT 1.
DOMAIN 750 978 MIF4G.
REPEAT 779 826 HEAT 2.
REPEAT 827 900 HEAT 3.
REPEAT 901 939 HEAT 4.
REPEAT 940 979 HEAT 5.
DOMAIN 1215 1337 MI.
DOMAIN 1410 1579 W2.
REGION 134 162 PABPC1-binding (By similarity).
REGION 614 625 EIF4E-binding (By similarity).
REGION 694 1014 eIF3/EIF4A-binding (By similarity).
REGION 1427 1579 EIF4A-binding (By similarity).
REGION 1565 1579 Necessary but not sufficient for MKNK1-
MOD_RES 230 230 Phosphoserine (By similarity).
MOD_RES 232 232 Phosphoserine (By similarity).
MOD_RES 240 240 Phosphoserine.
MOD_RES 267 267 Phosphoserine.
MOD_RES 470 470 Phosphoserine.
MOD_RES 472 472 Phosphoserine.
MOD_RES 490 490 Phosphoserine (By similarity).
MOD_RES 1150 1150 Phosphoserine; by CaMK1 (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; Repeat; RNA-binding; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1579 AA |
Protein Sequence | MNSQPQARSP FFQRPQIQPP RAAIPNSSPS IRPGVQTPTA VYQANQHIMM VNHLPMPYPV 60
TQGHQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFANAYGT PFYPSQPVYQ 120
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPASTPTP 180
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVFQS PSTVLRLVLS 240
GEKKEQAGQM PETAAGEPTP EPPRTSSPTS LPPLARSSLP SPMSAALSSQ PLFTAEDKCE 300
LPSSKEEDAP PVPSPTSCTA ASGPSLTDNS DICKKPCSVA PHDSQLISST ILINEMNGVG 360
EKLSAKENTV GMLRQEVLPL TLELEILEHP QEELKVECTP TPIAPSMLPA FSPAPPTPPT 420
SPPCPPVVLS AAIARSPAVA TEVQRVADEG ESLRTCLSKD AKEMQDKAES ESDGQAEETA 480
DPQSLHSGRS PAPVQTATTA PKSWKKTKEQ TRTPDEVLEA EAEPKAEEEL AVDSVLEPEQ 540
EKMSQGFPSE RDPSALKRGK AEEGNGEEAE PVRNGAESAS EGEGGDGNSG SADSSADGLT 600
FPFKAESWKP ADTEGKKQYD REFLLDIQFM PACIQKPEGL PPISDVVLDK INQPRLSMRT 660
LDPRILPRGP DFTPAFADFP RQTPGGRGVP LLNVGPRRSQ PGQRREPRKI ITVSVKEDVH 720
LRKAENAWKP SQKRDSHADD PESIKTQELF RKVRSILNKL TPQMFNQLMK QVSALTVDTE 780
ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF 840
EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML 900
TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ MEKIVKERKT 960
SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI EEQEEQRKVQ QLMTKEKRRP 1020
GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA 1080
SESDALRSSA SSLNRFSPLQ PPAPSGSPSA TPLEFDSRRA LTSRGSMGRE KSDKPIPAGT 1140
ARPNTFLRGS SKDLLDNQSQ EEQRREMLET VKQLTGGLDA ERASTEADRS KTRELAKSEM 1200
CAVPAPDKPA LSEEEVERKS KSIIDEFLHI NDFKEATQCI EELSAQGPLH VFVKVGVEFT 1260
LERSQITRDH MGHLLYQLVQ SEKLSKQDFF KGFSETLELA DDMAIDIPHI WLYLAELVTP 1320
MLKEGGISMR ELIVEFSKPL LPVGRAGVLL SEILHLLCRQ MSHKKVGALW READLSWKDF 1380
LPEGEDVHHF LLEQKLDFTE SEGPCSSEAL SKKELSAEEL SQRLEKLIME EKADDERIFD 1440
WVEANLDESQ MSSPTFLRAL MTAVCKAAII ADCSTFRVDT AVIKQRVPIL LKYLDSDTEK 1500
ELQALYALQA SIVKLDQPAN LLRMFFDCLY DEEVISEDAF YKWESSKDPA EQAGKGVALK 1560
SVTAFFTWLR EAEEESEDN 1579 |
Gene Ontology | GO:0003677; F:DNA binding; IEA:InterPro. GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. GO:0060903; P:positive regulation of meiosis I; IMP:MGI. GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI. GO:0045727; P:positive regulation of translation; IMP:MGI. GO:0016070; P:RNA metabolic process; IEA:InterPro. GO:0007283; P:spermatogenesis; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |