UniProt Accession

 GAMT_MOUSE; O35969; Q3TZ58; Q3US90 

Genbank Protein ID

 AF015887; AF010499; AF010498; AK140688; AK158087; BC049233 

Genbank Nucleotide ID

 AAB81495.1; AAB81498.1; AAB81498.1; BAE24443.1; BAE34352.1; AAH49233.1 

Protein Name

 Guanidinoacetate N-methyltransferase 

Protein Synonyms/Alias

  

Gene Name

 Gamt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	THLQILGKPVMERWE	ubiquitination	[1]
181	WGELMKSKYTDITTM	ubiquitination	[1]
235	MITPLVTKH******	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 DOMAIN 13 236 RMT2.
 REGION 69 74 S-adenosyl-L-methionine binding (By
 REGION 90 92 S-adenosyl-L-methionine (By similarity).
 REGION 117 118 S-adenosyl-L-methionine binding (By
 REGION 171 172 Substrate binding (By similarity).
 BINDING 20 20 S-adenosyl-L-methionine (By similarity).
 BINDING 42 42 Substrate (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 50 50 S-adenosyl-L-methionine (By similarity).
 BINDING 135 135 S-adenosyl-L-methionine and substrate (By  

Keyword

 Alternative splicing; Cell projection; Complete proteome; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
 GO:0030731; F:guanidinoacetate N-methyltransferase activity; ISS:UniProtKB.
 GO:0006601; P:creatine biosynthetic process; IMP:MGI.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 

Interpro

 IPR016550; GuanidinoAc_N-MeTrfase.
 IPR026480; RMT2_dom. 

Pfam

  

SMART

  

PROSITE

 PS51559; SAM_RMT2 

PRINTS