| Tag | Content |
|---|
| CPLM ID | CPLM-018550 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Disks large homolog 2 |
Protein Synonyms/Alias | Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93 |
Gene Name | Dlg2 |
Gene Synonyms/Alias | Dlgh2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 332 | GRYSPIPKHMLGEDD | ubiquitination | [1] | | 357 | TVNKLCDKPASPRHY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. |
Sequence Annotation | DOMAIN 98 185 PDZ 1.
DOMAIN 193 280 PDZ 2.
DOMAIN 421 502 PDZ 3.
DOMAIN 536 606 SH3.
DOMAIN 662 837 Guanylate kinase-like.
MOD_RES 28 28 Phosphoserine.
MOD_RES 58 58 Phosphotyrosine.
MOD_RES 62 62 Phosphoserine.
MOD_RES 175 175 Phosphoserine.
MOD_RES 340 340 Phosphotyrosine.
MOD_RES 348 348 Phosphotyrosine.
MOD_RES 365 365 Phosphoserine.
MOD_RES 406 406 Phosphoserine.
MOD_RES 414 414 Phosphoserine.
MOD_RES 500 500 Phosphotyrosine.
MOD_RES 505 505 Phosphotyrosine.
MOD_RES 732 732 Phosphotyrosine.
MOD_RES 737 737 Phosphotyrosine.
LIPID 5 5 S-palmitoyl cysteine (By similarity).
LIPID 7 7 S-palmitoyl cysteine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; SH3 domain; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 852 AA |
Protein Sequence | MFFACYCALR TNVKKYRYQD EDGPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL 60
QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH 120
IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY 180
VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ 240
VGDRLLMVNN YSLEEVTHEE AVAILKNTSD VVYLKVGKPT TIYMTDPYGP PDITHSYSPP 300
MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLGEDDY TRPPEPVYST VNKLCDKPAS 360
PRHYSPVECD KSFLLSTPYP HYHLGLLPDS DMTSHSQHST ATRQPSVTLQ RAISLEGEPR 420
KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH 480
EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY 540
VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVTLDGDS EEMGVIPSKR 600
RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS YEPVTRQEIN 660
YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VISREQMEKD 720
IQEHKFIEAG QYNDNLYGTS VQSVRFVAER GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP 780
KSLEPLMEMN KRLTEEQAKK TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS 840
GPFIWIPSKE KL 852 |
Gene Ontology | GO:0030054; C:cell junction; IDA:MGI. GO:0044224; C:juxtaparanode region of axon; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IDA:MGI. GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. GO:0019233; P:sensory perception of pain; IMP:MGI. GO:0007268; P:synaptic transmission; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |