CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009529
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S ribosomal protein L18a 
Protein Synonyms/Alias
  
Gene Name
 Rpl18a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
11SGTLREYKVVGRCLPacetylation[1, 2, 3]
11SGTLREYKVVGRCLPsuccinylation[2]
11SGTLREYKVVGRCLPubiquitination[4]
52WYFVSQLKKMKKSSGacetylation[5]
70YCGQVFEKSPLRVKNacetylation[5]
70YCGQVFEKSPLRVKNubiquitination[4]
76EKSPLRVKNFGIWLRacetylation[2, 5]
76EKSPLRVKNFGIWLRsuccinylation[2]
128AHSIQIMKVEEIAAGacetylation[5]
136VEEIAAGKCRRPAVKacetylation[2]
136VEEIAAGKCRRPAVKsuccinylation[2]
136VEEIAAGKCRRPAVKubiquitination[4]
170HKPRFTTKRPNTFF*acetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
 MOD_RES 63 63 Phosphotyrosine (By similarity).
 MOD_RES 71 71 Phosphoserine (By similarity).
 MOD_RES 123 123 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 176 AA 
Protein Sequence
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE 60
IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL TTAGAVTQCY RDMGARHRAR 120
AHSIQIMKVE EIAAGKCRRP AVKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF 176 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR021138; Ribosomal_L18a.
 IPR023573; Ribosomal_L18a/LX. 
Pfam
 PF01775; Ribosomal_L18ae 
SMART
  
PROSITE
  
PRINTS