UniProt Accession

 KAPCB_RAT; P68182; P05206 

Genbank Protein ID

 D10770 

Genbank Nucleotide ID

 BAA01601.1 

Protein Name

 cAMP-dependent protein kinase catalytic subunit beta 

Protein Synonyms/Alias

 PKA C-beta 

Gene Name

 Prkacb 

Gene Synonyms/Alias

 Pkacb 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
24	KEFLAKAKEDFLRKW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). 

Sequence Annotation

 DOMAIN 44 298 Protein kinase.
 DOMAIN 299 351 AGC-kinase C-terminal.
 NP_BIND 50 58 ATP (By similarity).
 ACT_SITE 167 167 Proton acceptor (By similarity).
 BINDING 73 73 ATP (By similarity).
 MOD_RES 3 3 Deamidated asparagine (By similarity).
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 49 49 Phosphothreonine (By similarity).
 MOD_RES 69 69 Phosphotyrosine (By similarity).
 MOD_RES 140 140 Phosphoserine (By similarity).
 MOD_RES 196 196 Phosphothreonine (By similarity).
 MOD_RES 198 198 Phosphothreonine (By similarity).
 MOD_RES 202 202 Phosphothreonine (By similarity).
 MOD_RES 331 331 Phosphotyrosine (By similarity).
 MOD_RES 339 339 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 ATP-binding; cAMP; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IDA:RGD.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0004691; F:cAMP-dependent protein kinase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0034237; F:protein kinase A regulatory subunit binding; IC:RGD.
 GO:0051447; P:negative regulation of meiotic cell cycle; IDA:RGD.
 GO:0097338; P:response to clozapine; IEP:RGD. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS