CPLM-027686

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-027686

UniProt Accession

Q91WT7_MOUSE; Q91WT7

Genbank Protein ID

AC122840; BC013482; BC026628; AY730283; AK033537; AK136528; CH466588

Genbank Nucleotide ID

AAH13482.1; AAH26628.1; AAU29338.1; BAC28346.1; BAE23028.1; EDL32237.1

Protein Name

3-alpha-hydroxysteroid dehydrogenase type 1

Protein Synonyms/Alias

Aldo-keto reductase family 1, member C14; Aldo-keto reductase family 1, member C14, isoform CRA_b; Protein Akr1c14

Gene Name

Akr1c14

Gene Synonyms/Alias

mCG_1727

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
28	FGTTVPDKVPKDELI	ubiquitination	[1]
36	VPKDELIKATKIAID	ubiquitination	[1]
39	DELIKATKIAIDTGF	ubiquitination	[1]
75	KIEDGTVKREDIFYT	ubiquitination	[1]
84	EDIFYTSKLWSTFHR	ubiquitination	[1]
101	LVRSCLEKTLKNAQL	ubiquitination	[1]
104	SCLEKTLKNAQLDYV	ubiquitination	[1]
161	CKDAGLAKSIGVSNF	ubiquitination	[1]
179	QLETILNKPGLKYKP	ubiquitination	[1]
225	TLGSSRDKIWVDQKS	ubiquitination	[1]
231	DKIWVDQKSPVLLDD	ubiquitination	[1]
247	VLCAMANKYKQTPAL	ubiquitination	[1]
249	CAMANKYKQTPALIA	ubiquitination	[1]
294	QLASEDMKVLDGLHR	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Sequence Annotation

ACT_SITE 55 55 Proton donor (By similarity).

Keyword

Complete proteome; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

323 AA

Protein Sequence

MNSVSPRVVL NDGHFIPALG FGTTVPDKVP KDELIKATKI AIDTGFRHFD SAYLYQIEEE 60
VGQAIRSKIE DGTVKREDIF YTSKLWSTFH RPELVRSCLE KTLKNAQLDY VDLYIIHFPM 120
ALQPGDKLFP RDEHGKLLAE AVDLCDTWEA MEKCKDAGLA KSIGVSNFNF RQLETILNKP 180
GLKYKPVCNQ VECHLYLNQS QMLDYCKSKD IILVSYCTLG SSRDKIWVDQ KSPVLLDDPV 240
LCAMANKYKQ TPALIAIRYQ LQRGIVVLTR SFKEKRIKEF MKVFEFQLAS EDMKVLDGLH 300
RNLRYNTASY FDDHPNHPFT DEY 323

Gene Ontology

GO:0047023; F:androsterone dehydrogenase activity; IDA:MGI.
GO:0021766; P:hippocampus development; IEA:Compara.

Interpro

IPR001395; Aldo/ket_red.
IPR018170; Aldo/ket_reductase_CS.
IPR020471; Aldo/keto_reductase_subgr.
IPR023210; NADP_OxRdtase_dom.

Pfam

PF00248; Aldo_ket_red

SMART

PROSITE

PS00798; ALDOKETO_REDUCTASE_1
PS00062; ALDOKETO_REDUCTASE_2

PRINTS

PR00069; ALDKETRDTASE.