UniProt Accession

 NUP57_YEAST; P48837; D6VUQ0 

Genbank Protein ID

 X81155; X83099; AY723815; Z72904; Z72905; BK006941 

Genbank Nucleotide ID

 CAA57053.1; CAA58153.1; AAU09732.1; CAA97129.1; CAA97131.1; DAA08211.1 

Protein Name

 Nucleoporin NUP57 

Protein Synonyms/Alias

 Nuclear pore protein NUP57 

Gene Name

 NUP57 

Gene Synonyms/Alias

 YGR119C; G6320 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
382	ILNHILEKSTQLQQK	acetylation	[1]
435	PLGIAEEKMWSQFQT	ubiquitination	[2]
471	AILKERAKNISSQLD	ubiquitination	[2]
489	MVFNDDTKNQDSMSK	ubiquitination	[2]
496	KNQDSMSKGTGEESN	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport. 

Sequence Annotation

 REPEAT 2 3 FG 1.
 REPEAT 11 12 FG 2.
 REPEAT 21 24 FXFG 1.
 REPEAT 39 42 FXFG 2.
 REPEAT 56 57 FG 3.
 REPEAT 65 66 FG 4.
 REPEAT 76 79 GLFG 1.
 REPEAT 103 106 GLFG 2.
 REPEAT 120 123 GLFG 3.
 REPEAT 132 135 GLFG 4.
 REPEAT 147 150 GLFG 5.
 REPEAT 175 178 GLFG 6.
 REPEAT 190 193 GLFG 7.
 REPEAT 204 207 GLFG 8.
 REPEAT 220 223 GLFG 9.  

Keyword

 Coiled coil; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 541 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0044613; C:nuclear pore central transport channel; IDA:SGD.
 GO:0005487; F:nucleocytoplasmic transporter activity; IGI:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IDA:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006607; P:NLS-bearing substrate import into nucleus; IGI:SGD.
 GO:0006999; P:nuclear pore organization; IMP:SGD.
 GO:0036228; P:protein targeting to nuclear inner membrane; IGI:SGD. 

Interpro

 IPR025574; Nucleoporin_FG_rpt.
 IPR024864; Nup54/Nup57/Nup44.
 IPR025712; Nup54_alpha-helical_dom. 

Pfam

 PF13634; Nucleoporin_FG
 PF13874; Nup54 

SMART

  

PROSITE

  

PRINTS