UniProt Accession

 NACB2_YEAST; P40314; D6VSN2 

Genbank Protein ID

 X78724; Z70202; Z68329; AY557726; BK006938 

Genbank Nucleotide ID

 CAA55370.1; CAA94091.1; CAA92709.1; AAS56052.1; DAA12092.1 

Protein Name

 Nascent polypeptide-associated complex subunit beta-2 

Protein Synonyms/Alias

 NAC-beta-2; BTF3 homolog BTT1; Beta-2-NAC 

Gene Name

 BTT1 

Gene Synonyms/Alias

 YDR252W; YD9320A.02 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
143	GDRCSETKQQVMNS*	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acts as component of the nascent polypeptide-associated complex (NAC), which promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane. Also blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. BTT1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II. 

Sequence Annotation

 DOMAIN 38 103 NAC-A/B.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0030014; C:CCR4-NOT complex; IPI:SGD.
 GO:0005854; C:nascent polypeptide-associated complex; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0051082; F:unfolded protein binding; IMP:SGD.
 GO:0051083; P:'de novo' cotranslational protein folding; IPI:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR027129; Btt1_fungal.
 IPR002715; Nas_poly-pep-assoc_cplx_dom. 

Pfam

 PF01849; NAC 

SMART

  

PROSITE

 PS51151; NAC_AB 

PRINTS