CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004260
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-hydroxytryptamine receptor 2A 
Protein Synonyms/Alias
 5-HT-2; 5-HT-2A; Serotonin receptor 2A 
Gene Name
 Htr2a 
Gene Synonyms/Alias
 Htr2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
277SDLSTRAKLASFSFLubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. 
Sequence Annotation
 MOTIF 469 471 PDZ-binding.
 CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 44 44 N-linked (GlcNAc...) (Potential).
 CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 DISULFID 148 227 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MEILCEDNIS LSSIPNSLMQ LGDGPRLYHN DFNSRDANTS EASNWTIDAE NRTNLSCEGY 60
LPPTCLSILH LQEKNWSALL TTVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD 120
MLLGFLVMPV SMLTILYGYR WPLPSKLCAI WIYLDVLFST ASIMHLCAIS LDRYVAIQNP 180
IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF 240
VAFFIPLTIM VITYFLTIKS LQKEATLCVS DLSTRAKLAS FSFLPQSSLS SEKLFQRSIH 300
REPGSYAGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNENVIGA 360
LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENRKPLQLIL VNTIPALAYK 420
SSQLQVGQKK NSQEDAEQTV DDCSMVTLGK QQSEENCTDN IETVNEKVSC V 471 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0043198; C:dendritic shaft; IDA:RGD.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0071886; F:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0001965; F:G-protein alpha-subunit binding; IMP:RGD.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:Compara.
 GO:0051378; F:serotonin binding; IDA:RGD.
 GO:0004993; F:serotonin receptor activity; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0008219; P:cell death; IMP:RGD.
 GO:0070371; P:ERK1 and ERK2 cascade; IEA:Compara.
 GO:0007613; P:memory; IMP:RGD.
 GO:0043267; P:negative regulation of potassium ion transport; IMP:RGD.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IMP:RGD.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Compara.
 GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; IDA:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:1900482; P:positive regulation of diacylglycerol biosynthetic process; IEA:InterPro.
 GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; IEA:InterPro.
 GO:0043406; P:positive regulation of MAP kinase activity; IMP:RGD.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
 GO:0050795; P:regulation of behavior; IEA:InterPro.
 GO:0050880; P:regulation of blood vessel size; IEA:InterPro.
 GO:0014059; P:regulation of dopamine secretion; IMP:RGD.
 GO:0046883; P:regulation of hormone secretion; IEA:InterPro.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0042493; P:response to drug; IMP:RGD.
 GO:0019233; P:sensory perception of pain; IMP:RGD.
 GO:0030431; P:sleep; IMP:RGD.
 GO:0006939; P:smooth muscle contraction; IEA:InterPro.
 GO:0001659; P:temperature homeostasis; IMP:RGD. 
Interpro
 IPR000455; 5HT2A_rcpt.
 IPR002231; 5HT_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00516; 5HT2ARECEPTR.
 PR01101; 5HTRECEPTOR.
 PR00237; GPCRRHODOPSN.