UniProt Accession

 CRYL1_HUMAN; Q9Y2S2; A0PJ43; B3KN92; Q0VDI1; Q7Z4Z9; Q9P0G7 

Genbank Protein ID

 AF077049; AF087898; AF160216; AK024041; AL161715; AL590096; AL590096; AL161715; AL161715; AL590096; AL590096; AL161715; CH471075; CH471075; BC008562; BC071810; BC119660; BC119661 

Genbank Nucleotide ID

 AAD27782.1; AAP97197.1; AAF67017.1; BAG51254.1; CAH71074.1; CAH71074.1; CAI14389.1; CAI14389.1; CAH71073.1; CAH71073.1; CAI14388.1; CAI14388.1; EAX08259.1; EAX08260.1; AAH08562.2; AAH71810.1; AAI19661.2; AAI19662.2 

Protein Name

 Lambda-crystallin homolog 

Protein Synonyms/Alias

 L-gulonate 3-dehydrogenase; Gul3DH 

Gene Name

 CRYL1 

Gene Synonyms/Alias

 CRY 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
188	QCPMRVQKEVAGFVL	ubiquitination	[1, 2]
279	FSRATAEKVNQDMCM	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 NP_BIND 16 17 NAD.
 BINDING 36 36 NAD.
 BINDING 97 97 NAD.
 BINDING 102 102 NAD.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050104; F:L-gulonate 3-dehydrogenase activity; IDA:UniProtKB.
 GO:0070403; F:NAD+ binding; IDA:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:InterPro. 

Interpro

 IPR022694; 3-OHacyl-CoA_DH.
 IPR006180; 3-OHacyl-CoA_DH_CS.
 IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
 IPR006108; 3HC_DH_C.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00725; 3HCDH
 PF02737; 3HCDH_N 

SMART

  

PROSITE

 PS00067; 3HCDH 

PRINTS