CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021769
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospholipid scramblase 1 
Protein Synonyms/Alias
 PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Transplantability-associated protein 1; NOR1; TRA1 
Gene Name
 Plscr1 
Gene Synonyms/Alias
 Tra1b; Tras1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
141TNNKYEIKNSLGQRVubiquitination[1]
267DEESVVGKISKQWSGubiquitination[1]
270SVVGKISKQWSGFVRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. 
Sequence Annotation
 MOTIF 18 26 SH3-binding 1 (Potential).
 MOTIF 22 25 WW-binding (Potential).
 MOTIF 56 64 SH3-binding 2 (Potential).
 MOTIF 93 101 SH3-binding 3 (Potential).
 MOTIF 269 275 Nuclear localization signal (By
 MOD_RES 83 83 Phosphotyrosine; by ABL (By similarity).
 MOD_RES 170 170 Phosphothreonine; by PKC (By similarity).
 LIPID 193 193 S-palmitoyl cysteine (By similarity).
 LIPID 194 194 S-palmitoyl cysteine (By similarity).
 LIPID 197 197 S-palmitoyl cysteine (By similarity).
 LIPID 198 198 S-palmitoyl cysteine (By similarity).  
Keyword
 Antiviral defense; Calcium; Chromosomal rearrangement; Complete proteome; DNA-binding; Lipoprotein; Membrane; Nucleus; Palmitate; Phosphoprotein; Reference proteome; Repeat; SH3-binding; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MENHSKQTEA PHPGTYMPAG YPPPYPPAAF QGPSDHAAYP IPQAGYQGPP GPYPGPQPGY 60
PVPPGGYAGG GPSGFPVQNQ PAYNHPGGPG GTPWMPAPPP PLNCPPGLEY LAQIDQLLVH 120
QQIELLEVLT GFETNNKYEI KNSLGQRVYF AVEDTDCCTR NCCGASRPFT LRILDNLGRE 180
VMTLERPLRC SSCCFPCCLQ EIEIQAPPGV PVGYVTQTWH PCLPKFTLQN EKKQDVLKVV 240
GPCVVCSCCS DIDFELKSLD EESVVGKISK QWSGFVREAF TDADNFGIQF PLDLDVKMKA 300
VMLGACFLID FMFFERTGNE EQRSGAWQ 328 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031012; C:extracellular matrix; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0045121; C:membrane raft; ISS:UniProtKB.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.
 GO:0017128; F:phospholipid scramblase activity; ISS:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:UniProtKB.
 GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
 GO:0006953; P:acute-phase response; IEP:UniProtKB.
 GO:0071345; P:cellular response to cytokine stimulus; IEP:UniProtKB.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.
 GO:0051607; P:defense response to virus; IMP:UniProtKB.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:MGI.
 GO:0030099; P:myeloid cell differentiation; IMP:MGI.
 GO:0032091; P:negative regulation of protein binding; IDA:MGI.
 GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
 GO:0006659; P:phosphatidylserine biosynthetic process; IDA:UniProtKB.
 GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IDA:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:2000373; P:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; ISS:UniProtKB.
 GO:0045089; P:positive regulation of innate immune response; IMP:UniProtKB.
 GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.
 GO:0033003; P:regulation of mast cell activation; ISS:UniProtKB.
 GO:0035455; P:response to interferon-alpha; IMP:UniProtKB.
 GO:0010225; P:response to UV-C; IDA:UniProtKB. 
Interpro
 IPR005552; Scramblase. 
Pfam
 PF03803; Scramblase 
SMART
  
PROSITE
  
PRINTS