UniProt Accession

 MED31_DROME; Q8IH24; A4V2E4; Q9VN40 

Genbank Protein ID

 AE014297; AE014297; AY061423; BT001465 

Genbank Nucleotide ID

 AAF52111.1; AAN13286.1; AAL28971.1; AAN71220.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 31 

Protein Synonyms/Alias

 Mediator complex subunit 31; Protein SOH1; dSOH1 

Gene Name

 MED31 

Gene Synonyms/Alias

 Trap18; CG1057 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKMYGKGKT	acetylation	[1]
7	*MAKMYGKGKTAIES	acetylation	[1]
9	AKMYGKGKTAIESEE	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene. 

Sequence Annotation

  

Keyword

 Activator; Alternative splicing; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; IDA:UniProtKB.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; ISS:FlyBase.
 GO:0008595; P:anterior/posterior axis specification, embryo; IMP:FlyBase.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB. 

Interpro

 IPR008831; Mediator_Med31. 

Pfam

 PF05669; Med31 

SMART

  

PROSITE

  

PRINTS