CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 
Protein Synonyms/Alias
  
Gene Name
 PPRC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166REGSSLHKLLTLSRTubiquitination[1, 2]
518ESGPLQGKGKPRAWAacetylation[2, 3]
520GPLQGKGKPRAWARAacetylation[2, 3]
1285RRVVFIGKIPGRMTRubiquitination[1]
1339AAIESGHKLRQADEQubiquitination[1]
1379DFDPAPVKSKFDSLDubiquitination[4]
1381DPAPVKSKFDSLDFDubiquitination[1, 4]
1392LDFDTLLKQAQKNLRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1400 AA 
Protein Sequence
MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD 60
SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE 120
DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI 180
TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP 240
QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE 300
SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE 360
IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE 420
KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR 480
SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL 540
ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV 600
LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP 660
SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK 720
TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP 780
SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA 840
SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP 900
SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS 960
VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG 1020
TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK 1080
ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL 1140
RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG 1200
NSGSSCSSSG RSRRCSSSSS SSSSSSSSSS SSSSSRSRSR SPSPRRRSDR RRRYSSYRSH 1260
DHYQRQRVLQ KERAIEERRV VFIGKIPGRM TRSELKQRFS VFGEIEECTI HFRVQGDNYG 1320
FVTYRYAEEA FAAIESGHKL RQADEQPFDL CFGGRRQFCK RSYSDLDSNR EDFDPAPVKS 1380
KFDSLDFDTL LKQAQKNLRR 1400 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS