| Tag | Content |
|---|
| CPLM ID | CPLM-021748 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF14 |
Protein Synonyms/Alias | Androgen receptor-associated protein 54; Protein Triad2; RING finger protein 14 |
Gene Name | Rnf14 |
Gene Synonyms/Alias | Ara54; Triad2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 257 | DYFEIQIKDGQVKCL | ubiquitination | [1] | | 352 | YHGLSPCKVTAEKLI | ubiquitination | [1] | | 357 | PCKVTAEKLIDLRNE | ubiquitination | [1] | | 400 | ESKDWLEKNSKSCPC | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity). |
Sequence Annotation | DOMAIN 11 137 RWD.
ZN_FING 221 271 RING-type 1; atypical.
ZN_FING 290 351 IBR-type.
ZN_FING 405 434 RING-type 2; degenerate.
MOTIF 37 45 D-box.
MOD_RES 349 349 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Ligase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 485 AA |
Protein Sequence | MSAEDLEAQE DELLALASIY DADEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNESLQN 60
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGR 120
VVLFAWMQFL KEETLTYLNI VSPFELKMGS QKKVQRRATA QASSSTELGV GGAAAADVDQ 180
EETVDERAVQ DVESLSSLIQ EILDFNQARQ TKCFNSKLFL CSICFCEKLG SDCMYFLECK 240
HVYCKACLKD YFEIQIKDGQ VKCLNCPEPQ CPSVATPGQV KELVEADLFA RYDRLLLQST 300
LDLMADVVYC PRPCCQLPVM QEPGGTMAIC SSCNFAFCTL CRLTYHGLSP CKVTAEKLID 360
LRNEYLQADE ATKRFLEQRY GKRVIQKALE EMESKDWLEK NSKSCPCCGT PIQKLDGCNK 420
MTCTGCMQYF CWICMGSLSR ANPYRHFTDS ESPCFNRLFH AVDINGDMWE DEIEEDDDDE 480
DDDDD 485 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0050681; F:androgen receptor binding; ISS:UniProtKB. GO:0019787; F:small conjugating protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0060765; P:regulation of androgen receptor signaling pathway; ISS:UniProtKB. GO:0032355; P:response to estradiol stimulus; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |