| Tag | Content |
|---|
| CPLM ID | CPLM-016070 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein VAC14 homolog |
Protein Synonyms/Alias | |
Gene Name | Vac14 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 21 | IVRALNDKLYEKRKV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity). |
Sequence Annotation | REPEAT 5 42 HEAT 1.
REPEAT 89 126 HEAT 2.
REPEAT 171 208 HEAT 3.
REPEAT 212 249 HEAT 4.
REPEAT 439 476 HEAT 5.
REPEAT 561 599 HEAT 6.
REGION 774 778 Mediates interaction with the PDZ domain
MOD_RES 11 11 Phosphothreonine (By similarity).
MOD_RES 500 500 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Endosome; Membrane; Microsome; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 783 AA |
Protein Sequence | MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVRDF VAQNNTVQIK HVIQTLSQEF 60
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDADSRLR YYACEALYNI 120
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESSK FDLVGFIPLL 180
RERIYSNNQY ARQFIISWIL VLVSVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL 240
GEFLKEIKKN PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 300
LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDEPD EPKSVAQKQT EPNPEDSLPK 360
QEGTASGGAS GPCDSSFGSG ISVFTSASTD RAPVTLHLDG IVQVLNCHLS DTTIGMMTRI 420
AVLKWLYHLY IKTPRKMFRH TDSLFPILLQ TLSDESDEVV LKDLEVLAEI ASSPAGQTDD 480
PGAPDGPDLQ VNHSELQVPT SGRANLLNPP NTKGLECSPS TPTMNSYFYK FMINLLQTFS 540
SERKLLEARG PFIIRQLCLL LNAENIFHSM ADILLREEDL KFASTMVHTL NTILLTSTEL 600
FQLRNQLKDL KTLESQNLFC CLYRSWCHNP VTTVSLCFLT QNYRHAYDLI QKFGDLEVTV 660
DFLTEVDKLV QLIECPIFTY LRLQLLDVKN NPYLMKALYG LLMLLPQSSA FQLLSHRLQC 720
VPNPELLQTE DCLKAAPKSQ KGDSPSIDYT ELLQHFEKVQ KQHLEVRHQR SGRGDHLDRR 780
VVL 783 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0019209; F:kinase activator activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |