CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-7B 
Protein Synonyms/Alias
 Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform 
Gene Name
 Myh7b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
249DNSSRFGKFIRIHFGacetylation[1]
664LHKENLNKLMTNLRAubiquitination[2]
769QYQFGHTKVFFKAGLubiquitination[2]
959DECTELKKDIDDLELubiquitination[2]
1398EELEEAKKKLALRLQubiquitination[2]
1764EAEEKAKKAITDAAMubiquitination[2]
1777AMMAEELKKEQDTSAubiquitination[2]
1778MMAEELKKEQDTSAHubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in muscle contraction (By similarity). 
Sequence Annotation
 DOMAIN 86 773 Myosin head-like.
 DOMAIN 788 817 IQ.
 NP_BIND 177 184 ATP (By similarity).
 REGION 662 684 Actin-binding (By similarity).
 REGION 764 778 Actin-binding (By similarity).  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Membrane; Motor protein; Muscle protein; Myosin; Nucleotide-binding; Reference proteome; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1941 AA 
Protein Sequence
MMDMSELGES ACYLRQGYQE MMKVHTVPWD GKKRVWVPDE QDAYVEAEVK TEATGGKVTV 60
ETKDQKVLTV RETEMQPMNP PRFDLLEDMA MMTHLNEAAV LHNLRQRYAR WMIYTYSGLF 120
CVTINPYKWL PVYTAAVVAA YKGKRRSEAP PHIYAVADNA YNDMLRNREN QSMLITGESG 180
AGKTVNTKRV IQYFAIVAAL GDGPGKKAQF LATKTGGTLE DQIIEANPAM EAFGNAKTLR 240
NDNSSRFGKF IRIHFGPTGK LASADIDSYL LEKSRVIFQL PGERGYHVYY QILSGKKPEL 300
QDMLLLSMNP YDYHFCSQGV TTVDNMDDGE ELIATDHAMD ILGFSVDEKC ACYKIVGALL 360
HFGNMKFKQK QREEQAEADG TESADKAAYL MGVSSGDLLK GLLHPRVRVG NEYVTKGQSV 420
EQVVFAVGAL AKATYDRLFR WLVSRINQTL DTKLPRQFFI GVLDIAGFEI FEFNSFEQLC 480
INFTNEKLQQ FFNQHMFVLE QEEYKREGID WVFIDFGLDL QPCIDLIEKP LGILSILEEE 540
CMFPKASDAS FRAKLYDNHS GKSPNFQQPR PDKKRKYQAH FEVVHYAGVV PYSIVGWLEK 600
NKDPLNETVV PIFQKSQNRL LATLYENYAG SCSTEPPKSG VKEKRKKAAS FQTVSQLHKE 660
NLNKLMTNLR ATQPHFVRCI VPNENKTPGV MDSFLVLHQL RCNGVLEGIR ICRQGFPNRL 720
LYADFRQRYR ILNPSAIPDD TFVDSRKATE KLLGSLDIDH TQYQFGHTKV FFKAGLLGIL 780
EELRDQRLAK VLTLLQARSR GRLMRLEYQR MLGGRDALFT IQWNIRAFNA VKNWSWMKLF 840
FKMKPLLRSA QAEEELAALR AELRGLRGAL ATAEAKRQEL EETQVSVTQE KNDLALQLQA 900
EQDNLADAEE RCHLLIKSKV QLEAKVKELS ERLEDEEEVN ADLAARRRKL EDECTELKKD 960
IDDLELTLAK AEKEKQATEN KVKNLTEEMA ALDEAVVRLT KEKKALQEAH QQALGDLQAE 1020
EDRVSALAKA KIRLEQQVED LECSLEQEKK LRMDTERAKR KLEGDLKLTQ ETVTDTTQDK 1080
QQLEEKLKKK DSELSQLNLR VEDEQLVGVQ LQKKIKELQA RAEELEEELE AERAARARVE 1140
KQRAEAAREL EELSERLEEA GGASAGQREG CRKREAELGR LRRELEEAVL RHEATVAALR 1200
RKQADSAAEL SEQVDSLQRI RQKLEKEKSE LRMEVDDLGA SVETLARGKA SAEKLCRTYE 1260
DQLSEAKIKV EELQRQLADA STQRGRLQTE NGELGRLLEE KESMISQLSR GKTSAAQSLE 1320
ELRRQLEEES KAKGALAHAV QALRHDCDLL REQHEEESEA QAELQRLLSK ANAEVAQWRS 1380
KYEADAIQRT EELEEAKKKL ALRLQEAEEG VEAANAKCSS LEKAKLRLQT ESEDVTLELE 1440
RATSAAAALD KKQRHLERAL EERRRQEEEM QRELEAAQRE ARGLGTELFR LRHSHEEALE 1500
ALETLKRENK NLQEEISDLT DQVSLSGKSI QELEKAKKAL EGEKSELQAA LEEAEGALEL 1560
EETKTLRIQL ELSQVKAEVD RKLAEKDEEC TNLRRNHQRA VESLQASLDA ETRARNEALR 1620
LKKKMEGDLN DLELQLGHAT RQAMEAQAAT RLLQAQLKEE QAGRDEEQRL AAELREQGQA 1680
LERRAALLAA ELEELRAALE QGERSRRLAE QELLEATERL NLLHSQNTGL LNQKKKLEVD 1740
LAQLSGEVEE AAQERREAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KTLEQTVREL 1800
QARLEEAEQA ALRGGKKQVQ KLEAKVRELE AELDAEQKKH AEALKGVRKH ERRVKELVYQ 1860
TEEDRKNLAR MQDLVDKLQS KVKSYKRQFE EAEQQASTNL AKYRKAQHEL DDAEERADMA 1920
ETQANKLRAR SRDALGPKHK E 1941 
Gene Ontology
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.