Tag | Content |
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CPLM ID | CPLM-011674 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/arginine-rich splicing factor 5 |
Protein Synonyms/Alias | Delayed-early protein HRS; Insulin-induced growth response protein CL-4; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5 |
Gene Name | Srsf5 |
Gene Synonyms/Alias | Cl-4; Hrs; Sfrs5 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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25 | KDVERFFKGYGRIRD | acetylation | [1] | 36 | RIRDIDLKRGFGFVE | acetylation | [1] | 163 | DLKNAIEKLSGKEIN | acetylation | [1] | 167 | AIEKLSGKEINGRKI | acetylation | [1] | 175 | EINGRKIKLIEGSKR | acetylation | [1] | 181 | IKLIEGSKRHRSRSR | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre- mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus. |
Sequence Annotation | DOMAIN 4 74 RRM 1. DOMAIN 108 181 RRM 2. MOD_RES 167 167 N6-acetyllysine (By similarity). MOD_RES 224 224 Phosphoserine (By similarity). MOD_RES 226 226 Phosphoserine (By similarity). MOD_RES 228 228 Phosphoserine (By similarity). MOD_RES 230 230 Phosphoserine (By similarity). MOD_RES 245 245 Phosphoserine (By similarity). MOD_RES 247 247 Phosphoserine (By similarity). MOD_RES 250 250 Phosphoserine (By similarity). MOD_RES 260 260 Phosphoserine (By similarity). MOD_RES 262 262 Phosphoserine (By similarity). MOD_RES 264 264 Phosphoserine (By similarity). MOD_RES 267 267 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 269 AA |
Protein Sequence | MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA DDAVYELDGK 60 ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN APPVRTENRL IVENLSSRVS 120 WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE FASYGDLKNA IEKLSGKEIN GRKIKLIEGS 180 KRHRSRSRSR SRTRSSSRSR SRSRSRRSKS YSRSRSRSRS RSKSRSGSRS PVPEKSQKRG 240 SSSRSKSPAS VDRQRSRSRS RSRSVDSGN 269 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |