CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029793
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxysterol-binding protein 
Protein Synonyms/Alias
  
Gene Name
 OSBPL9 
Gene Synonyms/Alias
 hCG_1780933 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
395RLGMDLTKVVLPTFIubiquitination[1]
621IFSPNDKKSFCSIEGubiquitination[1]
650NTVFVDTKKLPIIKKacetylation[2]
675YESRSLWKDVTFNLKubiquitination[1, 3]
710EARERKEKEIQWETRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lipid transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 741 AA 
Protein Sequence
MPYRRVTSGR LLSLAAPKMA SIMEGPLSKW TNVMKGWQYR WFVLDYNAGL LSYYTSKDKM 60
MRGSRRGCVR LRGAVIGIDD EDDSTFTITV DQKTFHFQAR DADEREKWIH ALEETILRHT 120
LQLQGLDSGF VPSVQDFDKK LTEADAYLQI LIEQLKLFDD KLQNCKEDEQ RKKIETLKET 180
TNSMVESIKH CIVLLQIAKS TINPVDAIYQ PSPLEPVIST MPSQTVLPPE PVQLCKSEQR 240
PSSLPVGPVL ATLGHHQTPT PNSTGSGHSP PSSSLTSPSH VNLSPNTVPE FSYSSSEDEF 300
YDADEFHQSG SSPKRLIDSS GSASVLTHSS SGNSLKRPDT TESLNSSLSN GTSDADLFDS 360
HDDRDDDAEA GSVEEHKSVI MHLLSQVRLG MDLTKVVLPT FILERRSLLE MYADFFAHPD 420
LFVSISDQKD PKDRMVQVVK WYLSAFHAGR KGSVAKKPYN PILGEIFQCH WTLPNDTEEN 480
TELVSEGPVP WVSKNSVTFV AEQVSHHPPI SAFYAECFNK KIQFNAHIWT KSKFLGMSIG 540
VHNIGQGCVS CLDYDEHYIL TFPNGYGRSI LTVPWVELGG ECNINCSKTG YSANIIFHTK 600
PFYGGKKHRI TAEIFSPNDK KSFCSIEGEW NGVMYAKYAT GENTVFVDTK KLPIIKKKVR 660
KLEDQNEYES RSLWKDVTFN LKIRDIDAAT EAKHRLEERQ RAEARERKEK EIQWETRLFH 720
EDGECWVYDE PLLKRLGAAK H 741 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW. 
Interpro
 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01237; Oxysterol_BP
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS01013; OSBP
 PS50003; PH_DOMAIN 
PRINTS