| Tag | Content |
|---|
| CPLM ID | CPLM-023109 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein kinase C and casein kinase substrate in neurons protein 3 |
Protein Synonyms/Alias | SH3 domain-containing protein 6511 |
Gene Name | PACSIN3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | QTRESHAKADSAVSQ | ubiquitination | [1] |
|
Reference | [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR. J Biol Chem. 2011 Dec 2;286(48):41530-8. [ PMID: 21987572] |
Functional Description | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). |
Sequence Annotation | DOMAIN 10 73 FCH.
DOMAIN 363 424 SH3.
REGION 1 304 F-BAR domain (By similarity).
MOD_RES 276 276 Phosphoserine.
MOD_RES 319 319 Phosphoserine.
MOD_RES 324 324 Phosphothreonine.
MOD_RES 327 327 Phosphoserine.
MOD_RES 354 354 Phosphoserine.
MOD_RES 383 383 Phosphoserine. |
Keyword | Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 424 AA |
Protein Sequence | MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 60
ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE KLQGQDSERV RAWQRGAFHR 120
PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV EASKKSYHAA RKDEKTAQTR ESHAKADSAV 180
SQEQLRKLQE RVERCAKEAE KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL 240
FFKDMLLTLH QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE 300
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD EEWSDEESPR 360
KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG WCQGQLQSGR IGLYPANYVE 420
CVGA 424 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0019855; F:calcium channel inhibitor activity; ISS:UniProtKB. GO:0008092; F:cytoskeletal protein binding; ISS:UniProtKB. GO:0008289; F:lipid binding; IDA:UniProtKB. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0097320; P:membrane tubulation; IDA:UniProtKB. GO:0051926; P:negative regulation of calcium ion transport; ISS:UniProtKB. GO:0045806; P:negative regulation of endocytosis; ISS:UniProtKB. GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |