CPLM-022967

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-022967

UniProt Accession

S12A6_HUMAN; Q9UHW9; A0AV76; Q2VI00; Q7Z2E7; Q7Z4G5; Q8TDD4; Q9UFR2; Q9Y642; Q9Y665

Genbank Protein ID

AF116242; AF108831; AF105366; AF314956; AF314931; AF314933; AF314934; AF314935; AF314936; AF314937; AF314938; AF314939; AF314940; AF314941; AF314942; AF314943; AF314944; AF314945; AF314946; AF314947; AF314948; AF314949; AF314950; AF314951; AF314952; AF314953; AF314954; AF314955; AF314956; AF314932; AF314933; AF314934; AF314935; AF314936; AF314937; AF314938; AF314939; AF314940; AF314941; AF314942; AF314943; AF314944; AF314945; AF314946; AF314947; AF314948; AF314949; AF314950; AF314951; AF314952; AF314953; AF314954; AF314955; AF531258; AF531259; AF531260; DQ138323; AK315283; AC021822; AC079203; CH471125; CH471125; CH471125; BC126241; BC126243; AF477977; AL117500

Genbank Nucleotide ID

AAF24986.1; AAD25337.1; AAD39742.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96215.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAM96216.1; AAQ10026.1; AAQ10027.1; AAQ10028.1; ABA02873.1; BAG37692.1; EAW92295.1; EAW92297.1; EAW92301.1; AAI26242.1; AAI26244.1; AAL85335.1; CAB55965.1

Protein Name

Solute carrier family 12 member 6

Protein Synonyms/Alias

Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3

Gene Name

SLC12A6

Gene Synonyms/Alias

KCC3

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
176	AENITEGKKKPTKTP	ubiquitination	[1]
600	RLLQAIAKDNIIPFL	ubiquitination	[1]
724	IEYQGAEKEWGDGIR	ubiquitination	[1]
772	LDEDLHVKHPRLLTF	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.

Sequence Annotation

MOD_RES 32 32 Phosphoserine.
MOD_RES 1007 1007 Phosphoserine (By similarity).
MOD_RES 1032 1032 Phosphoserine.
CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).
CARBOHYD 411 411 N-linked (GlcNAc...) (Potential).
CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).

Keyword

Alternative promoter usage; Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1150 AA

Protein Sequence

MHPPETTTKM ASVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES VPETSRSEPM 60
SEMSGATTSL ATVALDPPSD RTSHPQDVIE DLSQNSITGE HSQLLDDGHK KARNAYLNNS 120
NYEEGDEYFD KNLALFEEEM DTRPKVSSLL NRMANYTNLT QGAKEHEEAE NITEGKKKPT 180
KTPQMGTFMG VYLPCLQNIF GVILFLRLTW VVGTAGVLQA FAIVLICCCC TMLTAISMSA 240
IATNGVVPAG GSYFMISRAL GPEFGGAVGL CFYLGTTFAA AMYILGAIEI FLVYIVPRAA 300
IFHSDDALKE SAAMLNNMRV YGTAFLVLMV LVVFIGVRYV NKFASLFLAC VIVSILAIYA 360
GAIKSSFAPP HFPVCMLGNR TLSSRHIDVC SKTKEINNMT VPSKLWGFFC NSSQFFNATC 420
DEYFVHNNVT SIQGIPGLAS GIITENLWSN YLPKGEIIEK PSAKSSDVLG SLNHEYVLVD 480
ITTSFTLLVG IFFPSVTGIM AGSNRSGDLK DAQKSIPIGT ILAILTTSFV YLSNVVLFGA 540
CIEGVVLRDK FGDAVKGNLV VGTLSWPSPW VIVIGSFFST CGAGLQSLTG APRLLQAIAK 600
DNIIPFLRVF GHSKANGEPT WALLLTAAIA ELGILIASLD LVAPILSMFF LMCYLFVNLA 660
CALQTLLRTP NWRPRFRYYH WALSFMGMSI CLALMFISSW YYAIVAMVIA GMIYKYIEYQ 720
GAEKEWGDGI RGLSLSAARF ALLRLEEGPP HTKNWRPQLL VLLKLDEDLH VKHPRLLTFA 780
SQLKAGKGLT IVGSVIVGNF LENYGEALAA EQTIKHLMEA EKVKGFCQLV VAAKLREGIS 840
HLIQSCGLGG MKHNTVVMGW PNGWRQSEDA RAWKTFIGTV RVTTAAHLAL LVAKNISFFP 900
SNVEQFSEGN IDVWWIVHDG GMLMLLPFLL KQHKVWRKCS IRIFTVAQLE DNSIQMKKDL 960
ATFLYHLRIE AEVEVVEMHD SDISAYTYER TLMMEQRSQM LRHMRLSKTE RDREAQLVKD 1020
RNSMLRLTSI GSDEDEETET YQEKVHMTWT KDKYMASRGQ KAKSMEGFQD LLNMRPDQSN 1080
VRRMHTAVKL NEVIVNKSHE AKLVLLNMPG PPRNPEGDEN YMEFLEVLTE GLERVLLVRG 1140
GGSEVITIYS 1150

Gene Ontology

GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0015379; F:potassium:chloride symporter activity; IDA:UniProtKB.
GO:0001525; P:angiogenesis; NAS:UniProtKB.
GO:0071477; P:cellular hypotonic salinity response; IDA:UniProtKB.
GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.

Interpro

IPR004841; AA-permease_dom.
IPR018491; K/Cl_cotranspt_1/3.
IPR000076; KCL_cotranspt.
IPR004842; Na/K/Cl_cotransptS.

Pfam

PF00324; AA_permease
PF03522; KCl_Cotrans_1

SMART

PROSITE

PRINTS

PR01081; KCLTRNSPORT.