CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011644
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase complex subunit CTI6 
Protein Synonyms/Alias
 CYC8-TUP1-interacting protein 6; Transcriptional regulatory protein CTI6 
Gene Name
 CTI6 
Gene Synonyms/Alias
 RXT1; YPL181W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
9ESTAIVPKGPVVGSEubiquitination[1]
145IYKPVQEKRRQSRRKacetylation[2]
258QYQRMLEKALKESRRacetylation[2]
328SKEQSMEKTNDVEKEacetylation[2]
334EKTNDVEKEASQEKEacetylation[2]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters. 
Sequence Annotation
 ZN_FING 72 123 PHD-type.
 MOD_RES 174 174 Phosphothreonine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 177 177 Phosphothreonine.
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.  
Keyword
 Chromatin regulator; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MESTAIVPKG PVVGSEDMEK AEVIASGSTD IISTTSTATT TAAIGSVQEE SVKQEDVPME 60
GGEGEVEEEE GETRCICGEL DTPDDSGFFI QCEQCSSWQH GYCVSITQDN APDKYWCEQC 120
RPELHQLFTT DTGEARSIYK PVQEKRRQSR RKARSAAASK SHAANEAEKS PRNTSNTDDN 180
VDDIGDEEDE VEDEASAVAL AKDGNTRSSR RRRRNSMDDA STDQYSLDPG DSDKKLLDRK 240
RATFMAREEK QYQRMLEKAL KESRRTSHQE DPESYENDAD IYQGDTDNHN GTTRLQTDVM 300
LTEGKPDSVT NDDMKESLRP SKEQSMEKTN DVEKEASQEK ESSTGSAQDT EKTDEPILPL 360
TSISSSEDDS RKASSRGSKR VSKPARKGNR TRRSNTSSDT NQNRRSADIG TDKPVKPRLP 420
PQRTSLNEMR RRVSAILEFI SRTQWELSED QSDREEFVRF VENQHFVEKV DTIYNGYNES 480
LSMMDDLTRE LLLWEKKYSN NTNAIQ 506 
Gene Ontology
 GO:0033698; C:Rpd3L complex; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0035064; F:methylated histone residue binding; IDA:SGD.
 GO:0008134; F:transcription factor binding; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0061188; P:negative regulation of chromatin silencing at rDNA; IMP:SGD.
 GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.
 GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD 
SMART
 SM00249; PHD 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS