UniProt Accession

 EIF3C_HUMAN; Q99613; A8K7Z0; B2RXG3; O00215; Q9BW98 

Genbank Protein ID

 U46025; AC002544; U91326; AK000739; AK292155; BC000533; BC001571; BC071705; BC157842; BC157849; CH878380; BT007335 

Genbank Nucleotide ID

 AAD03462.1; AAC27426.1; AAC27674.1; BAA91352.1; BAF84844.1; AAH00533.1; AAH01571.1; AAH71705.1; AAI57843.1; AAI57850.1; EAW50492.1; AAP35999.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit C 

Protein Synonyms/Alias

 eIF3c; Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110 

Gene Name

 EIF3C 

Gene Synonyms/Alias

 EIF3S8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	EEFELLGKAYGKAKS	ubiquitination	[1]
92	LLGKAYGKAKSIVDK	ubiquitination	[1]
124	LNELWEDKEGKKKMN	ubiquitination	[2]
331	ITHAVVIKKLNEILQ	ubiquitination	[1, 2]
513	RILHTYYKFDYKAHQ	ubiquitination	[2]
517	TYYKFDYKAHQRQLT	ubiquitination	[2]
531	TPPEGSSKSEQDQAE	ubiquitination	[1, 2]
558	LCKYIYAKDRTDRIR	acetylation	[3]
627	AFRQGLTKDAHNALL	ubiquitination	[2]
643	IQSSGRAKELLGQGL	ubiquitination	[1, 2, 4, 5]
664	ERNQEQEKVERRRQV	ubiquitination	[2]
712	ARRRMISKQFHHQLR	ubiquitination	[4, 5]
764	INEKMNGKVWDLFPE	ubiquitination	[2]
862	LALQLAEKLGSLVEN	ubiquitination	[1, 2, 4, 5]
877	NERVFDHKQGTYGGY	ubiquitination	[1, 2, 4, 5]
889	GGYFRDQKDGYRKNE	ubiquitination	[1, 2, 4, 5]
894	DQKDGYRKNEGYMRR	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. 

Sequence Annotation

 DOMAIN 712 846 PCI.
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 18 18 Phosphoserine.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 178 178 Phosphoserine (By similarity).
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 524 524 Phosphothreonine.
 MOD_RES 909 909 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 913 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IDA:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP.
 GO:0006413; P:translational initiation; IDA:UniProtKB. 

Interpro

 IPR027516; EIF3C.
 IPR008905; EIF3C_N_dom.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF05470; eIF-3c_N
 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS