UniProt Accession

 ROAA_HUMAN; Q99729; B3KNN5; D3DWP7; Q04150; Q8N7U3; Q9BQ99 

Genbank Protein ID

 M65028; U76713; AK054600; AK097657; CH471165; CH471165; CH471165; BC001616; BC002625; BC004561; BC009359; BC036708 

Genbank Nucleotide ID

 AAA36575.1; AAC50956.1; BAG51397.1; BAC05134.1; EAW53843.1; EAW53844.1; EAW53845.1; AAH01616.1; AAH02625.1; AAH04561.1; AAH09359.1; AAH36708.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A/B 

Protein Synonyms/Alias

 hnRNP A/B; APOBEC1-binding protein 1; ABBP-1 

Gene Name

 HNRNPAB 

Gene Synonyms/Alias

 ABBP1; HNRPAB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	DTSKKDLKDYFTKFG	ubiquitination	[1]
92	DLKDYFTKFGEVVDC	ubiquitination	[1]
126	KDAASVEKVLDQKEH	ubiquitination	[1]
155	MKKDPVKKIFVGGLN	ubiquitination	[1]
169	NPEATEEKIREYFGE	ubiquitination	[1]
223	FHTVSGSKCEIKVAQ	ubiquitination	[1]
232	EIKVAQPKEVYQQQQ	ubiquitination	[1]
271	QGSTNYGKSQRRGGH	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. 

Sequence Annotation

 DOMAIN 69 154 RRM 1.
 DOMAIN 153 233 RRM 2.
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 245 245 Dimethylated arginine; alternate.
 MOD_RES 245 245 Omega-N-methylarginine; alternate.
 MOD_RES 322 322 Dimethylated arginine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:HGNC.
 GO:0005634; C:nucleus; ISS:HGNC.
 GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; TAS:ProtInc.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0001837; P:epithelial to mesenchymal transition; ISS:HGNC.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:HGNC. 

Interpro

 IPR012956; CARG-binding_factor_N.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF08143; CBFNT
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS