UniProt Accession

 CCHL_HUMAN; P53701; B3KUS1; Q502X8 

Genbank Protein ID

 U36787; AF053015; AF053010; AF053011; AF053012; AF053013; AF053014; AK097815; CH471074; BC001691; BC095455 

Genbank Nucleotide ID

 AAB19007.1; AAC35274.1; AAC35274.1; AAC35274.1; AAC35274.1; AAC35274.1; AAC35274.1; BAG53533.1; EAW98783.1; AAH01691.1; AAH95455.1 

Protein Name

 Cytochrome c-type heme lyase 

Protein Synonyms/Alias

 CCHL; Holocytochrome c-type synthase 

Gene Name

 HCCS 

Gene Synonyms/Alias

 CCHL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	AMLKKGWKWKDEDIS	ubiquitination	[1]
145	KDEDISQKDMYNIIR	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Links covalently the heme group to the apoprotein of cytochrome c (By similarity). 

Sequence Annotation

 REPEAT 24 29 HRM 1.
 REPEAT 34 39 HRM 2.  

Keyword

 Complete proteome; Disease mutation; Heme; Iron; Lyase; Membrane; Metal-binding; Microphthalmia; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 268 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:ProtInc.
 GO:0004408; F:holocytochrome-c synthase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0055114; P:oxidation-reduction process; TAS:ProtInc. 

Interpro

 IPR000511; Cyt_C/C1_haem_lyase. 

Pfam

 PF01265; Cyto_heme_lyase 

SMART

  

PROSITE

 PS00821; CYTO_HEME_LYASE_1
 PS00822; CYTO_HEME_LYASE_2 

PRINTS