CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010670
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prostaglandin reductase 1 
Protein Synonyms/Alias
 PRG-1; 15-oxoprostaglandin 13-reductase; Dithiolethione-inducible gene 1 protein; D3T-inducible gene 1 protein; DIG-1; NADP-dependent leukotriene B4 12-hydroxydehydrogenase 
Gene Name
 Ptgr1 
Gene Synonyms/Alias
 Dig1; Ltb4dh 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
11AKTWTLKKHFEGFPTacetylation[1]
56YMRVAAKKLKEGDSMacetylation[1]
178GTAGSDEKVAYLKKLacetylation[1]
183DEKVAYLKKLGFDVAacetylation[1]
184EKVAYLKKLGFDVAFacetylation[1]
194FDVAFNYKTVKSLEEacetylation[1]
197AFNYKTVKSLEEALRacetylation[1]
295MNWVSEGKIRYHEYIacetylation[1]
318AAFMGMLKGDNLGKTacetylation[1]
324LKGDNLGKTIVKA**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12- oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). 
Sequence Annotation
 NP_BIND 152 155 NADP (By similarity).
 NP_BIND 239 245 NADP (By similarity).
 NP_BIND 270 272 NADP (By similarity).
 BINDING 178 178 NADP (By similarity).
 BINDING 193 193 NADP (By similarity).
 BINDING 217 217 NADP (By similarity).
 BINDING 321 321 NADP (By similarity).  
Keyword
 Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 329 AA 
Protein Sequence
MVQAKTWTLK KHFEGFPTDS NFELRTTELP PLNNGEVLLE ALFLSVDPYM RVAAKKLKEG 60
DSMMGEQVAR VVESKNSAFP TGTIVVALLG WTSHSISDGN GLRKLPAEWP DKLPLSLALG 120
TVGMPGLTAY FGLLDICGLK GGETVLVNAA AGAVGSVVGQ IAKLKGCKVV GTAGSDEKVA 180
YLKKLGFDVA FNYKTVKSLE EALRTASPDG YDCYFDNVGG EFSNTVILQM KTFGRIAICG 240
AISQYNRTGP CPPGPSPEVI IYQQLRMEGF IVTRWQGEVR QKALTDLMNW VSEGKIRYHE 300
YITEGFEKMP AAFMGMLKGD NLGKTIVKA 329 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0036132; F:13-prostaglandin reductase activity; IEA:EC.
 GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:EC.
 GO:0032440; F:2-alkenal reductase [NAD(P)] activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006693; P:prostaglandin metabolic process; IEA:GOC.
 GO:0009636; P:response to toxic substance; IEP:RGD. 
Interpro
 IPR013149; ADH_C.
 IPR002085; ADH_SF_Zn-type.
 IPR014190; B4_12hDH.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
  
PRINTS