CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005693
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium- and chloride-dependent glycine transporter 1 
Protein Synonyms/Alias
 GlyT-1; GlyT1; Solute carrier family 6 member 9 
Gene Name
 Slc6a9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
577DTLLQRLKNATKPSRacetylation[1]
581QRLKNATKPSRDWGPacetylation[1]
581QRLKNATKPSRDWGPubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. 
Sequence Annotation
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
 CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative promoter usage; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 638 AA 
Protein Sequence
MAVAHGPVAT SSPEQNGAVP SEATKKDQNL TRGNWGNQIE FVLTSVGYAV GLGNVWRFPY 60
LCYRNGGGAF MFPYFIMLVF CGIPLFFMEL SFGQFASQGC LGVWRISPMF KGVGYGMMVV 120
STYIGIYYNV VICIAFYYFF SSMTHVLPWA YCNNPWNTPD CAGVLDASNL TNGSRPTALS 180
GNLSHLFNYT LQRTSPSEEY WRLYVLKLSD DIGDFGEVRL PLLGCLGVSW VVVFLCLIRG 240
VKSSGKVVYF TATFPYVVLT ILFVRGVTLE GAFTGIMYYL TPKWDKILEA KVWGDAASQI 300
FYSLGCAWGG LITMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL GFMANHLGVD 360
VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL GLGTQFCLLE TLVTAIVDEV 420
GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ AGIYWLLLMD NYAASFSLVV ISCIMCVSIM 480
YIYGHRNYFQ DIQMMLGFPP PLFFQICWRF VSPTIIFFIL IFTVIQYRPI TYNHYQYPGW 540
AVAIGFLMAL SSVICIPLYA LFQLCRTDGD TLLQRLKNAT KPSRDWGPAL LEHRTGRYAP 600
TTTPSPEDGF EVQPLHPDKA QIPIVGSNGS SRLQDSRI 638 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0015187; F:glycine transmembrane transporter activity; TAS:RGD.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0005283; F:sodium:amino acid symporter activity; IEA:InterPro. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR003028; Na/ntran_symport_glycine_GLY1. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01204; GLY1TRNSPORT.
 PR00176; NANEUSMPORT.