CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase MGRN1 
Protein Synonyms/Alias
 Mahogunin RING finger protein 1 
Gene Name
 Mgrn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
102SLRLVRYKDDTDSPTubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). 
Sequence Annotation
 ZN_FING 278 317 RING-type.
 MOTIF 385 388 Required for TSG101-binding (By
 MOD_RES 502 502 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Endosome; Ligase; Lipoprotein; Membrane; Metal-binding; Myristate; Phosphoprotein; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MGSILSRRIA GVEDIDIQAN SAYRYPPKSA GNYFASHFFM GGEKFDTPHP EGYLFGENMD 60
LNFLGSRPVQ FPYVTPAPHE PVKTLRSLVN IRKDSLRLVR YKDDTDSPTE DGEKPRVLYS 120
LEFTFDADAR VAITIYCQAV EEFVNGMTVY SCKNPSLQSE TVHYKRGVSQ QFSLPSFKID 180
FSEWKDDELN FDLDRGVFPV VIQAVVDEGD VVEVTGHAHV LLAAFEKHVD GSFSVKPLKQ 240
KQIVDRVSYL LQEIYGIENK NNQETKPSDD ENSDNSSECV VCLSDLRDTL ILPCRHLCLC 300
TSCADTLRYQ ANNCPICRLP FRALLQIRAV RKKPGALSPI SFSPVLAQSV DHDEHSNSDS 360
VPPGYEPISL LEALNGLRAV SPAIPSAPLY EEITYSGISD GLSQASCPLA GLDRIIENGI 420
QKGKTQSKSP DSTLRSPSSP IHEEDEEKLS EDPEAPLPPS GVELVLQESS SPESFGTEEV 480
GEPSLKQGSR VPSIDDVLQD GSPQHHGCSQ PVPPADIYLP ALGPESCSVG IEE 533 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008333; P:endosome to lysosome transport; IEA:Compara.
 GO:0043951; P:negative regulation of cAMP-mediated signaling; ISS:UniProtKB.
 GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.
 GO:0006513; P:protein monoubiquitination; IEA:Compara.
 GO:0000209; P:protein polyubiquitination; IEA:Compara. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS