| Tag | Content |
|---|
| CPLM ID | CPLM-004217 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA polymerase zeta catalytic subunit |
Protein Synonyms/Alias | Protein reversionless 3 |
Gene Name | REV3 |
Gene Synonyms/Alias | PSO1; YPL167C; P2535 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 111 | VHKTLEVKIRASFKR | ubiquitination | [1] |
|
Reference | [1] A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O. Mol Cell Proteomics. 2011 May;10(5):M111.009753. [ PMID: 21427232] |
Functional Description | Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion. |
Sequence Annotation | ZN_FING 1398 1417 CysA-type.
MOTIF 1446 1473 CysB motif.
METAL 1398 1398 Zinc (By similarity).
METAL 1401 1401 Zinc (By similarity).
METAL 1414 1414 Zinc (By similarity).
METAL 1417 1417 Zinc (By similarity).
METAL 1446 1446 Iron-sulfur (4Fe-4S) (By similarity).
METAL 1449 1449 Iron-sulfur (4Fe-4S) (By similarity).
METAL 1468 1468 Iron-sulfur (4Fe-4S) (By similarity).
METAL 1473 1473 Iron-sulfur (4Fe-4S) (By similarity). |
Keyword | 4Fe-4S; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Nucleotidyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1504 AA |
Protein Sequence | MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL NQFSQVPNIR 60
VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR CAQVHKTLEV KIRASFKRKK 120
DDKHDLAGDK LGNLNFVADV SVVKGIPFYG YHVGWNLFYK ISLLNPSCLS RISELIRDGK 180
IFGKKFEIYE SHIPYLLQWT ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL 240
LLDRFCDFKC NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI 300
PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE AFYKKAQHKT 360
STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI EINNNSMQDK KNDDQVNASF 420
TEYEICGVDN ENEGVKGSNI KSRSYSWLPE SIASPKDSTI LLDHQTKYHN TINFSMDCAM 480
TQNMASKRKL RSSVSANKTS LLSRKRKKVM AAGLRYGKRA FVYGEPPFGY QDILNKLEDE 540
GFPKIDYKDP FFSNPVDLEN KPYAYAGKRF EISSTHVSTR IPVQFGGETV SVYNKPTFDM 600
FSSWKYALKP PTYDAVQKWY NKVPSMGNKK TESQISMHTP HSKFLYKFAS DVSGKQKRKK 660
SSVHDSLTHL TLEIHANTRS DKIPDPAIDE VSMIIWCLEE ETFPLDLDIA YEGIMIVHKA 720
SEDSTFPTKI QHCINEIPVM FYESEFEMFE ALTDLVLLLD PDILSGFEIH NFSWGYIIER 780
CQKIHQFDIV RELARVKCQI KTKLSDTWGY AHSSGIMITG RHMINIWRAL RSDVNLTQYT 840
IESAAFNILH KRLPHFSFES LTNMWNAKKS TTELKTVLNY WLSRAQINIQ LLRKQDYIAR 900
NIEQARLIGI DFHSVYYRGS QFKVESFLIR ICKSESFILL SPGKKDVRKQ KALECVPLVM 960
EPESAFYKSP LIVLDFQSLY PSIMIGYNYC YSTMIGRVRE INLTENNLGV SKFSLPRNIL 1020
ALLKNDVTIA PNGVVYAKTS VRKSTLSKML TDILDVRVMI KKTMNEIGDD NTTLKRLLNN 1080
KQLALKLLAN VTYGYTSASF SGRMPCSDLA DSIVQTGRET LEKAIDIIEK DETWNAKVVY 1140
GDTDSLFVYL PGKTAIEAFS IGHAMAERVT QNNPKPIFLK FEKVYHPSIL ISKKRYVGFS 1200
YESPSQTLPI FDAKGIETVR RDGIPAQQKI IEKCIRLLFQ TKDLSKIKKY LQNEFFKIQI 1260
GKVSAQDFCF AKEVKLGAYK SEKTAPAGAV VVKRRINEDH RAEPQYKERI PYLVVKGKQG 1320
QLLRERCVSP EEFLEGENLE LDSEYYINKI LIPPLDRLFN LIGINVGNWA QEIVKSKRAS 1380
TTTTKVENIT RVGTSATCCN CGEELTKICS LQLCDDCLEK RSTTTLSFLI KKLKRQKEYQ 1440
TLKTVCRTCS YRYTSDAGIE NDHIASKCNS YDCPVFYSRV KAERYLRDNQ SVQREEALIS 1500
LNDW 1504 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0016035; C:zeta DNA polymerase complex; IDA:SGD. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003887; F:DNA-directed DNA polymerase activity; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0006260; P:DNA replication; IEA:UniProtKB-KW. GO:0070987; P:error-free translesion synthesis; IDA:SGD. GO:0042276; P:error-prone translesion synthesis; IDA:SGD. |
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PRINTS | |