CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Steroid 21-hydroxylase 
Protein Synonyms/Alias
  
Gene Name
 Cyp21a1 
Gene Synonyms/Alias
 Cyp21 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
220LPNPGLQKLKQIQESubiquitination[1]
261YMLQGVEKQRDGKDEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MLLPGLLLLL LLLAGTRWLW GQWKLRKLHL PPPAPGFLHF LQPNLPIYLL GLTQKLGPIY 60
RIRLGLQDVV ALNSNRTIEE ALIQKWVDFA GRPQMLNGKM DLDLSLGDYS LMWKAHKKLS 120
RSALMLGMRD SMEPLIEQLT QEFCERMRAQ AGTPVAIHKE FSFLTCSIIS CLTFGDKDST 180
LVQTLHDRIQ DLLQAWNHWS IQILTIIPLL RFLPNPGLQK LKQIQESRDH IVKQQLKRHK 240
DSLVAGQWKD MIDYMLQGVE KQRDGKDEER LHEGHVHMSV VDMFIGGTET TATTLSWAVA 300
FLLHHPEIQK RLQEELDLKL GPGSQLLYRN RMQLLLLMAT IAEVLHLRPV VPLALPHRAT 360
RASSISGYDI PKDMVIIPNI QGANLDEMVW ELPSKFWPDC FLEPGKNPRT PSFGCGARVC 420
LGEPLARLEL FVVLARLLQA FALLPPPDGT LPSLQPQLYA GINFLIPPFQ VRLQPRNLAA 480
QELGEKSLTG 490 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.