| Tag | Content |
|---|
| CPLM ID | CPLM-019866 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epithelial cell adhesion molecule |
Protein Synonyms/Alias | Ep-CAM; Epithelial glycoprotein 314; EGP314; mEGP314; Protein 289A; Tumor-associated calcium signal transducer 1; CD326 |
Gene Name | Epcam |
Gene Synonyms/Alias | Tacstd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 304 | KYEKAEIKEMGEIHR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). |
Sequence Annotation | DOMAIN 63 135 Thyroglobulin type-1.
CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
DISULFID 27 46 By similarity.
DISULFID 29 59 By similarity.
DISULFID 38 48 By similarity.
DISULFID 66 99 By similarity.
DISULFID 110 116 By similarity.
DISULFID 118 135 By similarity. |
Keyword | Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 315 AA |
Protein Sequence | MAGPQALAFG LLLAVVTATL AAAQRDCVCD NYKLATSCSL NEYGECQCTS YGTQNTVICS 60
KLASKCLAMK AEMTHSKSGR RIKPEGAIQN NDGLYDPDCD EQGLFKAKQC NGTATCWCVN 120
TAGVRRTDKD TEITCSERVR TYWIIIELKH KERESPYDHQ SLQTALQEAF TSRYKLNQKF 180
IKNIMYENNV ITIDLMQNSS QKTQDDVDIA DVAYYFEKDV KGESLFHSSK SMDLRVNGEP 240
LDLDPGQTLI YYVDEKAPEF SMQGLTAGII AVIVVVSLAV IAGIVVLVIS TRKKSAKYEK 300
AEIKEMGEIH RELNA 315 |
Gene Ontology | GO:0016324; C:apical plasma membrane; ISS:MGI. GO:0016323; C:basolateral plasma membrane; ISS:MGI. GO:0009986; C:cell surface; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016328; C:lateral plasma membrane; ISS:UniProtKB. GO:0005923; C:tight junction; ISS:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0001657; P:ureteric bud development; IEP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |