UniProt Accession

 DECR2_HUMAN; Q9NUI1; Q6ZRS7; Q96ET0 

Genbank Protein ID

 AJ293009; AE006463; AK128012; AL023881; BC010740; BC011968 

Genbank Nucleotide ID

 CAC05664.1; AAK61231.1; BAC87232.1; CAB92744.1; AAH10740.1; AAH11968.1 

Protein Name

 Peroxisomal 2,4-dienoyl-CoA reductase 

Protein Synonyms/Alias

 pDCR; 2,4-dienoyl-CoA reductase 2 

Gene Name

 DECR2 

Gene Synonyms/Alias

 PDCR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	CPDLLRDKVAFITGG	ubiquitination	[1]
151	VSRVLYEKFFRDHGG	acetylation	[2]
291	DFASFSAKL******	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. 

Sequence Annotation

 NP_BIND 35 40 NADP.
 NP_BIND 60 64 NADP.
 NP_BIND 208 214 NADP.
 REGION 126 128 Substrate binding.
 MOTIF 290 292 Microbody targeting signal (By
 BINDING 60 60 Substrate.
 BINDING 86 86 NADP.
 BINDING 88 88 Substrate.
 BINDING 118 118 Substrate.
 BINDING 182 182 NADP.
 BINDING 219 219 Substrate.
 MOD_RES 151 151 N6-acetyllysine.
 MOD_RES 291 291 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Fatty acid metabolism; Lipid metabolism; NADP; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IDA:UniProtKB.
 GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IDA:UniProtKB.
 GO:0006636; P:unsaturated fatty acid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.