CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018853
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphomannomutase 1 
Protein Synonyms/Alias
 PMM 1; PMMH-22 
Gene Name
 PMM1 
Gene Synonyms/Alias
 PMMH22 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30TLTPARQKIDPEVAAubiquitination[1, 2, 3, 4, 5]
41EVAAFLQKLRSRVQIubiquitination[1, 4, 6]
177LKTEFAGKGLRFSRGubiquitination[6]
198VFPEGWDKRYCLDSLubiquitination[6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. 
Sequence Annotation
 ACT_SITE 19 19 Nucleophile.
 ACT_SITE 21 21
 ACT_SITE 54 54
 ACT_SITE 198 198
 METAL 218 218 Magnesium.
 BINDING 28 28 Substrate.
 BINDING 132 132 Substrate.
 BINDING 143 143 Substrate.
 BINDING 150 150 Substrate.
 BINDING 186 186 Substrate.
 BINDING 188 188 Substrate.
 BINDING 190 190 Substrate.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Isomerase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
MAVTAQAARR KERVLCLFDV DGTLTPARQK IDPEVAAFLQ KLRSRVQIGV VGGSDYCKIA 60
EQLGDGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR 120
LPKKRGTFIE FRNGMLNISP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR 180
FSRGGMISFD VFPEGWDKRY CLDSLDQDSF DTIHFFGNET SPGGNDFEIF ADPRTVGHSV 240
VSPQDTVQRC REIFFPETAH EA 262 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004615; F:phosphomannomutase activity; TAS:ProtInc.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome.
 GO:0009298; P:GDP-mannose biosynthetic process; TAS:Reactome.
 GO:0019307; P:mannose biosynthetic process; IEA:InterPro.
 GO:0006013; P:mannose metabolic process; TAS:ProtInc.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 
Interpro
 IPR023214; HAD-like_dom.
 IPR006379; HAD-SF_hydro_IIB.
 IPR005002; PMM. 
Pfam
 PF03332; PMM 
SMART
  
PROSITE
  
PRINTS