UniProt Accession

 PHF5A_MOUSE; P83870; Q3TQX7; Q9UH06 

Genbank Protein ID

 AF479286; AF479288; AK003520; AK143590; AK163247; AK167932; AK167955; BC025161 

Genbank Nucleotide ID

 AAM49735.1; AAM49736.1; BAB22833.1; BAE25453.1; BAE37255.1; BAE39936.1; BAE39955.1; AAH25161.1 

Protein Name

 PHD finger-like domain-containing protein 5A 

Protein Synonyms/Alias

 PHD finger-like domain protein 5A; Splicing factor 3B-associated 14 kDa protein; SF3b14b 

Gene Name

 Phf5a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKHHPDLIF	acetylation	[1, 2]
95	IVNLGSSKTDLFYER	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; DNA-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0016363; C:nuclear matrix; IDA:MGI.
 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0005686; C:U2 snRNP; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR005345; PHF5. 

Pfam

 PF03660; PHF5 

SMART

  

PROSITE

  

PRINTS