| Tag | Content |
|---|
| CPLM ID | CPLM-007041 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor SKN7 |
Protein Synonyms/Alias | Peroxide sensitivity protein 9 |
Gene Name | SKN7 |
Gene Synonyms/Alias | BRY1; POS9; YHR206W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 418 | SAISTLEKYRYDLVL | ubiquitination | [1] |
|
Reference | [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae. Starita LM, Lo RS, Eng JK, von Haller PD, Fields S. Proteomics. 2012 Jan;12(2):236-40. [ PMID: 22106047] |
Functional Description | Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two- component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. |
Sequence Annotation | DOMAIN 378 492 Response regulatory.
DNA_BIND 86 190 By similarity.
MOD_RES 427 427 4-aspartylphosphate. |
Keyword | Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 622 AA |
Protein Sequence | MSFSTINSNV NKTTGDSNNN TTENSSTADL LGMDLLQSGP RLMNTMQPNN SSDMLHINNK 60
TNNVQQPAGN TNISSANAGA KAPANEFVRK LFRILENNEY PDIVTWTENG KSFVVLDTGK 120
FTTHILPNHF KHSNFASFVR QLNKYDFHKV KRSPEERQRC KYGEQSWEFQ HPEFRVHYGK 180
GLDNIKRKIP AQRKVLLDES QKALLHFNSE GTNPNNPSGS LLNESTTELL LSNTVSKDAF 240
GNLRRRVDKL QKELDMSKME SYATKVELQK LNSKYNTVIE SLITFKTINE NLLNNFNTLC 300
STLANNGIEV PIFGDNGNRN PTGNTNPATT TAIQSNNNTN NASPATSTVS LQLPNLPDQN 360
SLTPNAQNNT VTLRKGFHVL LVEDDAVSIQ LCSKFLRKYG CTVQVVSDGL SAISTLEKYR 420
YDLVLMDIVM PNLDGATATS IVRSFDNETP IIAMTGNIMN QDLITYLQHG MNDILAKPFT 480
RDDLHSILIR YLKDRIPLCE QQLPPRNSSP QTHSNTNTAN SNPNTINEQS LAMLPQDNPS 540
TTTPVTPGAS ISSAQHVQQG QQEQQHQIFH AQQQQQHHNA IANARSDVAI PNLEHEINTV 600
PHSSMGSTPQ LPQSTLQENQ LS 622 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0000156; F:phosphorelay response regulator activity; IDA:SGD. GO:0043565; F:sequence-specific DNA binding; IDA:SGD. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:SGD. GO:0008361; P:regulation of cell size; IMP:SGD. GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IMP:SGD. GO:0006970; P:response to osmotic stress; TAS:SGD. GO:0000304; P:response to singlet oxygen; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IDA:SGD. |
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