UniProt Accession

 RSD_ECOLI; P0AFX4; P31690; Q2M8T2 

Genbank Protein ID

 D12624; U00006; U00096; AP009048 

Genbank Nucleotide ID

 AAC43093.1; AAC76969.1; BAE77324.1 

Protein Name

 Regulator of sigma D 

Protein Synonyms/Alias

  

Gene Name

 rsd 

Gene Synonyms/Alias

 b3995; JW3959 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
40	YYNLVGIKPGKESYM	acetylation	[1]
43	LVGIKPGKESYMRLN	acetylation	[1]
79	IYERILHKLEGNGQL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase. 

Sequence Annotation

 REGION 59 71 Interaction with RpoD.
 REGION 101 108 Interaction with RpoD.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000428; C:DNA-directed RNA polymerase complex; IDA:EcoCyc.
 GO:0016989; F:sigma factor antagonist activity; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001125; P:transcription termination from bacterial-type RNA polymerase promoter; IDA:EcoCyc. 

Interpro

 IPR023785; Sigma70_reg_Rsd.
 IPR007448; Sigma70_reg_Rsd_AlgQ. 

Pfam

 PF04353; Rsd_AlgQ 

SMART

  

PROSITE

  

PRINTS